TOP TEN perturbations for O60242 (Homo sapiens)

Organism: Homo sapiens
Gene: O60242
Selected probe(set): 205638_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of O60242 (205638_at) across 5392 perturbations tested by GENEVESTIGATOR:

brain tumor study 1 (ependymoma) / normal brain tissue

Relative Expression (log2-ratio):-3.635603
Number of Samples:46 / 12
Experimental brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)

Relative Expression (log2-ratio):3.3668852
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).

embryonic development study 1 (8wk) / embryonic development study 1 (4wk)

Relative Expression (log2-ratio):3.1324778
Number of Samples:3 / 3
Experimental embryonic development study 1 (8wk)
Human embryos at 8th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.
Control embryonic development study 1 (4wk)
Human embryos at 4th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.

glioma study 5 / non-tumor brain tissue

Relative Expression (log2-ratio):-3.0039854
Number of Samples:12 / 9
Experimental glioma study 5
Primary tumor tissue sample from the supratentorial brain of pediatric patients with glioblastoma multiformae.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):-2.92871
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

embryonic development study 1 (9wk) / embryonic development study 1 (4wk)

Relative Expression (log2-ratio):2.8196688
Number of Samples:3 / 3
Experimental embryonic development study 1 (9wk)
Human embryos at 9th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.
Control embryonic development study 1 (4wk)
Human embryos at 4th week after fertilization. Embryos were obtained after therapeutic termination of pregnancy with mifepristone.

lung adenocarcinoma study 6 (EGFR mut) / adjacent lung tissue

Relative Expression (log2-ratio):-2.6961393
Number of Samples:24 / 20
Experimental lung adenocarcinoma study 6 (EGFR mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying an EGFR mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

lung adenocarcinoma study 3 (positive) / normal lung tissue

Relative Expression (log2-ratio):-2.6181536
Number of Samples:7 / 3
Experimental lung adenocarcinoma study 3 (positive)
Primary lung adenocarcinoma samples, with bone marrow positive for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.

lung adenocarcinoma study 6 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-2.6089392
Number of Samples:6 / 20
Experimental lung adenocarcinoma study 6 (K-RAS mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (ependymoma)

Relative Expression (log2-ratio):2.5691586
Number of Samples:15 / 46
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.