TOP TEN perturbations for O60245 (Homo sapiens)

Organism: Homo sapiens
Gene: O60245
Selected probe(set): 228640_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of O60245 (228640_at) across 5610 perturbations tested by GENEVESTIGATOR:

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):7.3762293
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

Hep-G2 / HepaRG

Relative Expression (log2-ratio):-6.342456
Number of Samples:9 / 12
Experimental Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

CD44s overexpr. study 1 / normal HEK-293 cell sample

Relative Expression (log2-ratio):-5.847571
Number of Samples:3 / 3
Experimental CD44s overexpr. study 1
Human embryonic kidney cell line HEK-293 transfected with pcDNA3.1(-) vector containing codon-optimized human CD44 sequence for expression.
Control normal HEK-293 cell sample
Untransfected, native human embryonic kidney cell line HEK-293 cell samples.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):-5.599448
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

oxyphilic adenoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-5.5199423
Number of Samples:4 / 2
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue
Normal fetal kidney tissue samples.

ovarian tumor study 11 (borderline) / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):5.090415
Number of Samples:8 / 6
Experimental ovarian tumor study 11 (borderline)
Human microdissected tumor cells from the ovary of patients with low-malignant (borderline) tumors of the ovary.
Control normal ovarian surface epithelial cell sample
Human microdissected ovarian surface epithelial cell sample from the ovary of healthy individuals.

monocyte co-culture study 1 (HS27a) / monocyte co-culture study 1 (HS5)

Relative Expression (log2-ratio):5.013326
Number of Samples:2 / 2
Experimental monocyte co-culture study 1 (HS27a)
Bone marrow stromal cell line HS27a cultured with CD14+ monocytes from two different donors.
Control monocyte co-culture study 1 (HS5)
Bone marrow stromal cell line HS5 cultured with CD14+ monocytes from two different donors.

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):-4.924078
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

HS-27A / HS-5

Relative Expression (log2-ratio):4.874254
Number of Samples:4 / 4
Experimental HS-27A
Human bone marrow stromal cell line derived from a male Caucasian patient. Cells were immortalized by transduction with the human papilloma virus E6/E7 genes. HS-27a supports obblestone area formation by early hematopoietic progenitors. Synonyms:HS27A; HS27a; HS-27a; HS 27a Cellosaurus code:
Control HS-5
Human bone marrow stromal cell line of a 30 yeas old male Caucasian immortalized by transduction with the human papilloma virus E6/E7 genes. HS-5 secretes multiple cytokines that support the proliferation of committed progenitors. Synonyms:HS5; HS 5 Cellosaurus code:

RAF1 overexpr. study 1 (retrovirus) / control virus infected MCF7 cell sample

Relative Expression (log2-ratio):-4.7611074
Number of Samples:2 / 2
Experimental RAF1 overexpr. study 1 (retrovirus)
MCF-7 cell line stably transfected with retrovirus containing cDNA for RAF1. The following retroviral construct was used: pLNCRaf-1 contains human Raf-1 cDNA encoding an amino terminally truncated form of Raf-1 that is constitutively active, which is inserted into retroviral vector pLNCX encoding neomycin resistance gene (NeoR). MCF7 cells were maintained in EMEM supplemented with 10% FBS and 20ug/ml insulin.
Control control virus infected MCF7 cell sample
MCF7 cell line transfected with pZipneo retrovirus, which is an empty retroviral vector encoding neomycine resistance gene (NeoR). MCF7 cells were maintained in EMEM supplemented with 10% FBS and 20ug/ml insulin.