TOP TEN perturbations for O60260 (Homo sapiens)

Organism: Homo sapiens
Gene: O60260
Selected probe(set): 207058_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of O60260 (207058_s_at) across 5610 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-319) / normal astrocyte sample

Relative Expression (log2-ratio):2.175179
Number of Samples:2 / 3
Experimental glioma study 16 (LN-319)
Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

collecting duct carcinoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):-1.5246496
Number of Samples:2 / 3
Experimental collecting duct carcinoma study 1
Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control normal kidney tissue
Normal adult kidney tissue samples.

inclusion body myositis study 1 / normal biceps tissue

Relative Expression (log2-ratio):-1.4584951
Number of Samples:5 / 3
Experimental inclusion body myositis study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

nephroblastoma study 2 / normal kidney tissue

Relative Expression (log2-ratio):-1.443408
Number of Samples:4 / 3
Experimental nephroblastoma study 2
Tumor tissue samples from the kidney of patients with Wilms’ tumor.
Control normal kidney tissue
Normal adult kidney tissue samples.

Daoy-BMI1 KD-PCGF2 KD / Daoy-ALK KD

Relative Expression (log2-ratio):-1.2435808
Number of Samples:3 / 3
Experimental Daoy-BMI1 KD-PCGF2 KD
Daoy cells with knockdown of BMI1 and polycomb group ring finger 2 (PCGF2 or mel-18). Daoy cells are human primary cancer cell line derived from the cerebellum (posterior fossa) of a patient with desmoplastic medulloblastoma. Parental cell line:: Daoy
Control Daoy-ALK KD
Daoy cells with knockdown of anaplastic lymphoma kinase (ALK), which is only expressed in lymphoid cells. Daoy cells are human primary cancer cell line derived from the cerebellum (posterior fossa) of a patient with desmoplastic medulloblastoma. Parental cell line:: Daoy

polymyositis study 2 / dermatomyositis study 4

Relative Expression (log2-ratio):-1.186389
Number of Samples:2 / 3
Experimental polymyositis study 2
Deltoid biopsy muscle samples from patients with clinical diagnosis of polymyositis (PM).
Control dermatomyositis study 4
Deltoid biopsy muscle samples from patients with clinical diagnosis of dermatomyositis (DM).

Daoy-PCGF2 KD / Daoy-ALK KD

Relative Expression (log2-ratio):-1.1843672
Number of Samples:3 / 3
Experimental Daoy-PCGF2 KD
Daoy cells with knockdown of a polycomb group ring finger 2 (PCGF2 or mel-18). Daoy cells are human primary cancer cell line derived from the cerebellum (posterior fossa) of a patient with desmoplastic medulloblastoma. Parental cell line:: Daoy
Control Daoy-ALK KD
Daoy cells with knockdown of anaplastic lymphoma kinase (ALK), which is only expressed in lymphoid cells. Daoy cells are human primary cancer cell line derived from the cerebellum (posterior fossa) of a patient with desmoplastic medulloblastoma. Parental cell line:: Daoy

oxyphilic adenoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):1.1762333
Number of Samples:4 / 2
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue
Normal fetal kidney tissue samples.

renal cell carcinoma study 5 (papillary type) / normal kidney tissue

Relative Expression (log2-ratio):-1.095295
Number of Samples:19 / 3
Experimental renal cell carcinoma study 5 (papillary type)
Tumor tissue samples from the kidney of patients with papillary renal cell carcinoma (pRCC).
Control normal kidney tissue
Normal adult kidney tissue samples.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis study 9 (glomerulus)

Relative Expression (log2-ratio):1.0897198
Number of Samples:21 / 10
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis study 9 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.