TOP TEN perturbations for O95377 (Homo sapiens)

Organism: Homo sapiens
Gene: O95377
Selected probe(set): 206156_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of O95377 (206156_at) across 5339 perturbations tested by GENEVESTIGATOR:

esophageal adenocarcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):-3.8827362
Number of Samples:20 / 18
Experimental esophageal adenocarcinoma study 1
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

Barrett's esophagus study 3 / normal esophageal epithelium sample

Relative Expression (log2-ratio):-3.3384447
Number of Samples:17 / 18
Experimental Barrett's esophagus study 3
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

Merkel cell carcinoma study 3 (primary) / skin squamous cell carcinoma study 6

Relative Expression (log2-ratio):-3.2240973
Number of Samples:38 / 4
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).

Merkel cell carcinoma study 3 (primary) / normal skin tissue

Relative Expression (log2-ratio):-3.0688362
Number of Samples:38 / 64
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control normal skin tissue
Normal skin samples from healthy donors.

Merkel cell carcinoma study 3 (metastatic) / normal skin tissue

Relative Expression (log2-ratio):-3.0341473
Number of Samples:22 / 64
Experimental Merkel cell carcinoma study 3 (metastatic)
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control normal skin tissue
Normal skin samples from healthy donors.

lung squamous cell carcinoma study 1 / normal lung tissue

Relative Expression (log2-ratio):2.753337
Number of Samples:31 / 44
Experimental lung squamous cell carcinoma study 1
Primary lung squamous cell carcinoma samples of a patient with non-small cell lung cancer.
Control normal lung tissue
Histologically normal lung tissue.

non-small cell lung cancer study 8 (squamous cell carcinoma) / adjacent lung tissue

Relative Expression (log2-ratio):2.426978
Number of Samples:27 / 65
Experimental non-small cell lung cancer study 8 (squamous cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma.
Control adjacent lung tissue
Histological normal lung tissue samples from patients with lung cancer.

non-small cell lung cancer study 8 (squamous cell carcinoma) / non-small cell lung cancer study 8 (large cell carcinoma)

Relative Expression (log2-ratio):2.2847404
Number of Samples:27 / 18
Experimental non-small cell lung cancer study 8 (squamous cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma.
Control non-small cell lung cancer study 8 (large cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients large cell carcinoma.

atopic dermatitis study 12 (non-lesional; adults) / atopic dermatitis study 12 (non-lesional; children)

Relative Expression (log2-ratio):2.1569777
Number of Samples:20 / 19
Experimental atopic dermatitis study 12 (non-lesional; adults)
Unaffected skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis.
Control atopic dermatitis study 12 (non-lesional; children)
Unaffected buttock skin biopsy samples from pediatric patients (age range 3 months-5 years) with early-onset atopic dermatitis. All patients had moderate-to-severe disease (SCORAD score: mean, 57.8; range, 33-84) with recent-onset (within the previous 6 months). Systemic immunosuppressants within the past 4 weeks, topical steroids or immunomodulators within 1 week, or moisturizers within 12 hours before evaluation were restricted. Patients with active skin infections were excluded.

gefitinib study 2 / wild type A431 cell sample

Relative Expression (log2-ratio):-2.1273184
Number of Samples:3 / 3
Experimental gefitinib study 2
Gefitinib-resistant A431 (A431 GR) cells generated by growing parental cells in the presence of increasing concentrations of gefitinib up to 3 ?M. Cells were selected and maintained in gefitinib (3?M). ATC code:
Control wild type A431 cell sample
A431 wild type cells.