TOP TEN perturbations for O95377 (Homo sapiens)
Organism: Homo sapiens
Gene: O95377
Selected probe(set): 206156_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of O95377 (206156_at) across 5610 perturbations tested by GENEVESTIGATOR:
esophageal adenocarcinoma study 1 / normal esophageal epithelium sample
Relative Expression (log2-ratio):-3.8827362Number of Samples:20 / 18
Experimental | esophageal adenocarcinoma study 1 |
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique. | |
Control | normal esophageal epithelium sample |
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy. |
Barrett's esophagus study 3 / normal esophageal epithelium sample
Relative Expression (log2-ratio):-3.3384447Number of Samples:17 / 18
Experimental | Barrett's esophagus study 3 |
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection. | |
Control | normal esophageal epithelium sample |
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy. |
Merkel cell carcinoma study 3 (primary) / skin squamous cell carcinoma study 6
Relative Expression (log2-ratio):-3.2240973Number of Samples:38 / 4
Experimental | Merkel cell carcinoma study 3 (primary) |
Primary tumor tissue from the skin of patients with Merkel cell carcinoma. | |
Control | skin squamous cell carcinoma study 6 |
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC). |
Merkel cell carcinoma study 3 (primary) / normal skin tissue
Relative Expression (log2-ratio):-3.0688362Number of Samples:38 / 64
Experimental | Merkel cell carcinoma study 3 (primary) |
Primary tumor tissue from the skin of patients with Merkel cell carcinoma. | |
Control | normal skin tissue |
Normal skin samples from healthy donors. |
Merkel cell carcinoma study 3 (metastatic) / normal skin tissue
Relative Expression (log2-ratio):-3.0341473Number of Samples:22 / 64
Experimental | Merkel cell carcinoma study 3 (metastatic) |
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin. | |
Control | normal skin tissue |
Normal skin samples from healthy donors. |
lung squamous cell carcinoma study 1 / normal lung tissue
Relative Expression (log2-ratio):2.753337Number of Samples:31 / 44
Experimental | lung squamous cell carcinoma study 1 |
Primary lung squamous cell carcinoma samples of a patient with non-small cell lung cancer. | |
Control | normal lung tissue |
Histologically normal lung tissue. |
non-small cell lung cancer study 8 (squamous cell carcinoma) / adjacent lung tissue
Relative Expression (log2-ratio):2.426978Number of Samples:27 / 65
Experimental | non-small cell lung cancer study 8 (squamous cell carcinoma) |
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma. | |
Control | adjacent lung tissue |
Histological normal lung tissue samples from patients with lung cancer. |
non-small cell lung cancer study 8 (squamous cell carcinoma) / non-small cell lung cancer study 8 (large cell carcinoma)
Relative Expression (log2-ratio):2.2847404Number of Samples:27 / 18
Experimental | non-small cell lung cancer study 8 (squamous cell carcinoma) |
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma. | |
Control | non-small cell lung cancer study 8 (large cell carcinoma) |
Primary tumor tissue sample obtained from the lung of patients large cell carcinoma. |
atopic dermatitis study 12 (non-lesional; adults) / atopic dermatitis study 12 (non-lesional; children)
Relative Expression (log2-ratio):2.1569777Number of Samples:20 / 19
Experimental | atopic dermatitis study 12 (non-lesional; adults) |
Unaffected skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis. | |
Control | atopic dermatitis study 12 (non-lesional; children) |
Unaffected buttock skin biopsy samples from pediatric patients (age range 3 months-5 years) with early-onset atopic dermatitis. All patients had moderate-to-severe disease (SCORAD score: mean, 57.8; range, 33-84) with recent-onset (within the previous 6 months). Systemic immunosuppressants within the past 4 weeks, topical steroids or immunomodulators within 1 week, or moisturizers within 12 hours before evaluation were restricted. Patients with active skin infections were excluded. |
gefitinib study 2 / wild type A431 cell sample
Relative Expression (log2-ratio):-2.1273184Number of Samples:3 / 3
Experimental | gefitinib study 2 |
Gefitinib-resistant A431 (A431 GR) cells generated by growing parental cells in the presence of increasing concentrations of gefitinib up to 3 μM. Cells were selected and maintained in gefitinib (3μM). ATC code: | |
Control | wild type A431 cell sample |
A431 wild type cells. |