TOP TEN perturbations for O95497 (Homo sapiens)

Organism: Homo sapiens
Gene: O95497
Selected probe(set): 205844_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of O95497 (205844_at) across 5610 perturbations tested by GENEVESTIGATOR:

AsPC-1 / BxPC-3

Relative Expression (log2-ratio):8.933899
Number of Samples:3 / 3
Experimental AsPC-1
Human xenograft derived metastatic cancer cell line derived from mouse xenografts initiated with metastatic cells from the ascites derived from a 62 years old female Caucasian patient with pancreatic adenocarcinoma. Synonyms:AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 Cellosaurus code:
Control BxPC-3
Human pancreatic adenocarcinoma cell line derived from a 61 years old female patient. Synonyms:BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3 Cellosaurus code:

ulcerative colitis study 13 (inflamed) / normal colon epithelial cell sample

Relative Expression (log2-ratio):7.2632833
Number of Samples:3 / 3
Experimental ulcerative colitis study 13 (inflamed)
Colon epithelial cells from macroscopically inflamed gut areas derived from patients with established ulcerative colitis. Cells were obtained from microdissected epithelial fractions of surgically derived colon specimens. Histopathological examination of colon specimens displayed active lesions like erosions/ulcerations or crypt abscesses/cryptitis, and showed increased mononuclear infiltrates.
Control normal colon epithelial cell sample
Colon epithelial cells derived from microdissected epithelial fractions of normal colon tissue. Tissue was obtained during surgery from patients with tubulovillous adenoma of the colon or adenocarcinoma of the colon.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-7.2302504
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

PMA study 8 (0.0001 uM; Hep-G2) / vehicle (DMSO) treated Hep-G2 cell sample

Relative Expression (log2-ratio):6.044896
Number of Samples:3 / 9
Experimental PMA study 8 (0.0001 uM; Hep-G2)
Hep-G2 cells exposed to 0.0001 uM PMA (dissolved in 0.5% v/v DMSO) for 72 hours. Synonyms: phorbol-12-myristat-13-acetate (PMA), tetradecanoylphorbol-acetate (TPA), tetradecanoyl phorbol acetate, 12-O-tetradecanoylphorbol-13-acetate. Cells were exposed to the chemical when 80% confluence was reached. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:---
Control vehicle (DMSO) treated Hep-G2 cell sample
Hep-G2 cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Cells were exposed to the vehicle when 80% confluence was reached.

colorectal adenoma study 7 (colonic mucosa) / adjacent colon mucosa sample

Relative Expression (log2-ratio):-5.707947
Number of Samples:5 / 5
Experimental colorectal adenoma study 7 (colonic mucosa)
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal adenoma.
Control adjacent colon mucosa sample
Adjacent colon mucosa sample obtained by laser capture microdissection (LCM) from patients with colorectal cancer.

PMA study 6 (500ng/ml) / vehicle (DME) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):5.5318346
Number of Samples:3 / 17
Experimental PMA study 6 (500ng/ml)
Bronchial epithelial cells (NHBE) treated with tetradecanoylphorbol acetate (500ng/ml; vendor: Sigma / catalog number: P1585 / catalog name: Phorbol 12-myristate 13-acetate [16561-29-8]) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:---
Control vehicle (DME) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

ovulation study 3 / proliferative phase endometrium tissue

Relative Expression (log2-ratio):5.3963194
Number of Samples:5 / 4
Experimental ovulation study 3
Late secretory phase (LSE) endometrium tissue.
Control proliferative phase endometrium tissue
Proliferative phase (PE) endometrium tissue.

ulcerative colitis study 13 (inflamed) / ulcerative colitis study 13 (non-inflamed)

Relative Expression (log2-ratio):5.327549
Number of Samples:3 / 3
Experimental ulcerative colitis study 13 (inflamed)
Colon epithelial cells from macroscopically inflamed gut areas derived from patients with established ulcerative colitis. Cells were obtained from microdissected epithelial fractions of surgically derived colon specimens. Histopathological examination of colon specimens displayed active lesions like erosions/ulcerations or crypt abscesses/cryptitis, and showed increased mononuclear infiltrates.
Control ulcerative colitis study 13 (non-inflamed)
Colon epithelial cells from macroscopically non-inflamed gut areas derived from patients with established ulcerative colitis. Cells were obtained from microdissected epithelial fractions of surgically derived colon specimens. Histopathological examination of colon specimens displayed no active lesions like erosions/ulcerations or crypt abscesses/cryptitis, and showed no increase in mononuclear cell numbers.

Hep-G2 / HepaRG

Relative Expression (log2-ratio):-5.2689304
Number of Samples:9 / 12
Experimental Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

ovarian tumor study 28 (mucocarcinoid tumor) / ovarian tumor study 28 (endometrioid carcinoma)

Relative Expression (log2-ratio):5.138619
Number of Samples:7 / 6
Experimental ovarian tumor study 28 (mucocarcinoid tumor)
Primary tumor tissue sample obtained from the ovary of female patients with malignant mucocarcinoid tumor.
Control ovarian tumor study 28 (endometrioid carcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with endometrioid carcinoma.