TOP TEN perturbations for P02786 (Homo sapiens)

Organism: Homo sapiens
Gene: P02786
Selected probe(set): 208691_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P02786 (208691_at) across 5339 perturbations tested by GENEVESTIGATOR:

T-cell activation study 4 / normal resting T-cell sample

Relative Expression (log2-ratio):4.47281
Number of Samples:2 / 2
Experimental T-cell activation study 4
T-cell samples antiCD3 activated for 30hrs.
Control normal resting T-cell sample
T cells resting for 30h.

T-cell activation study 1 / quiescent CD4+ T-cell sample

Relative Expression (log2-ratio):3.280243
Number of Samples:2 / 2
Experimental T-cell activation study 1
CD4+ T-cell samples derived from PBMC?s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 1 day.
Control quiescent CD4+ T-cell sample
Quiescent CD4+ T-cell samples derived from PBMC?s of HIV-seronegative donors.

T-cell activation study 2 / quiescent CD4+ T-cell sample

Relative Expression (log2-ratio):3.188446
Number of Samples:2 / 2
Experimental T-cell activation study 2
CD4+ T-cell samples derived from PBMC?s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 2 days..
Control quiescent CD4+ T-cell sample
Quiescent CD4+ T-cell samples derived from PBMC?s of HIV-seronegative donors.

dermatomyositis study 3 / normal biceps tissue

Relative Expression (log2-ratio):-3.1555624
Number of Samples:5 / 3
Experimental dermatomyositis study 3
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of dermatomyositis (DM).
Control normal biceps tissue
Biceps femoris biopsy muscle samples from control subjects.

VTX-2337 study 1 / untreated monocyte sample

Relative Expression (log2-ratio):3.1392412
Number of Samples:3 / 3
Experimental VTX-2337 study 1
Peripheral blood monocytes isolated from healthy donors. Cells were treated overnight with 1uM VTX-2337 drug, which represents a TLR8 (Toll-like receptor 8) agonist with potential immunostimulating and antineoplastic activities.
Control untreated monocyte sample
Peripheral blood monocytes isolated from healthy donors.

necrotizing myopathy study 1 / dermatomyositis study 3

Relative Expression (log2-ratio):3.0131636
Number of Samples:3 / 5
Experimental necrotizing myopathy study 1
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).
Control dermatomyositis study 3
Biceps femoris biopsy muscle samples from patients with clinical diagnosis of dermatomyositis (DM).

Sjogren's syndrome study 1 (advanced) / normal minor salivary gland tissue

Relative Expression (log2-ratio):2.740902
Number of Samples:2 / 4
Experimental Sjogren's syndrome study 1 (advanced)
Whole minor salivary gland samples of patients with advanced Sjogren's syndrome.
Control normal minor salivary gland tissue
Whole minor salivary gland samples from non-Sjogren's syndrome control subjects.

IFN-g; LPS study 1 / normal resting monocyte sample

Relative Expression (log2-ratio):2.6456757
Number of Samples:2 / 2
Experimental IFN-g; LPS study 1
Monocytes LPS/IFN-g activated for 30h.
Control normal resting monocyte sample
Monocytes resting for 30h.

colorectal adenoma study 2 / normal colon tissue

Relative Expression (log2-ratio):-2.5206614
Number of Samples:5 / 6
Experimental colorectal adenoma study 2
Laser microdissected human adenoma sample.
Control normal colon tissue
Laser microdissected human colonic epithelial cells sample.

smoking study 27 (FF) / vehicle (PBS) treated bronchial/ tracheal epithelial cell sample

Relative Expression (log2-ratio):2.4510803
Number of Samples:2 / 2
Experimental smoking study 27 (FF)
Normal human bronchial/tracheal epithelial (NHBE) cells were treated for 18 hours with cigarette smoke condensates (CSCs) at doses that represent a final nicotine concentration of ~4 ?g/ml, prepared from commercial full flavor nonmenthol cigarettes (FF; nicotine: 0.9 mg/cigarette). Cigarette smoke was generated at the CSC under the standard Federal Trade Commission method (FTC; 35-ml puff volume, 2-s puff, and 1 min between puffs) using a single port smoking machine to a butt length of 23 mm or filter overwrap + 3 mm, whichever was greater. CSC were prepared by bubbling the mainstream smoke through 10 ml of PBS in a 30-ml midget bubbler; this solution, defined as "100% CSC", was filtered through a 0.22-?m filter, aliquoted, and kept frozen. To ensure consistency of exposures, separate aliquots of the frozen stock were used for each experiment.
Control vehicle (PBS) treated bronchial/ tracheal epithelial cell sample
Normal human bronchial/tracheal epithelial (NHBE) cells were treated for 18 hours with PBS.