TOP TEN perturbations for P07101 (Homo sapiens)

Organism: Homo sapiens
Gene: P07101
Selected probe(set): 208291_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P07101 (208291_s_at) across 5610 perturbations tested by GENEVESTIGATOR:

adrenal gland cancer study 4 / normal adrenal cortex tissue

Relative Expression (log2-ratio):-6.838521
Number of Samples:43 / 4
Experimental adrenal gland cancer study 4
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples derived after autopsy.

aldosterone-producing adenoma study 1 / normal adrenal gland tissue

Relative Expression (log2-ratio):-3.6278648
Number of Samples:9 / 5
Experimental aldosterone-producing adenoma study 1
Aldosterone-producing adenoma samples.
Control normal adrenal gland tissue
Normal adrenal gland samples.

Parkinson's disease study 6 / normal pars reticulata tissue

Relative Expression (log2-ratio):-3.4718122
Number of Samples:3 / 4
Experimental Parkinson's disease study 6
Pars reticulata tissue from patients with Parkinson's disease.
Control normal pars reticulata tissue
Normal pars reticulata tissue.

RAF1 depletion study 1 / normal SW-480 cell sample

Relative Expression (log2-ratio):-3.3455696
Number of Samples:6 / 3
Experimental RAF1 depletion study 1
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-480.
Control normal SW-480 cell sample
Non-transduced SW-480 colorectal cell line sample.

RAF1 depletion study 1 / mock transfected SW-480 cell sample

Relative Expression (log2-ratio):-3.3075504
Number of Samples:6 / 6
Experimental RAF1 depletion study 1
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-480.
Control mock transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with non-targeting pLKO_NonTarget vector.

RAF1 depletion study 1 / control vector transfected SW-480 cell sample

Relative Expression (log2-ratio):-3.0731382
Number of Samples:6 / 6
Experimental RAF1 depletion study 1
RNAi-mediated gene knockdown of RAF1 in colorectal cancer cell line SW-480.
Control control vector transfected SW-480 cell sample
SW-480 colorectal cell line sample transduced with empty vector pLKO.

Parkinson's disease study 10 / normal postmortem substantia nigra tissue

Relative Expression (log2-ratio):-2.8941536
Number of Samples:16 / 9
Experimental Parkinson's disease study 10
Substantia nigra tissue from postmortem brain of Parkinson's disease (PD) patients.
Control normal postmortem substantia nigra tissue
Substantia nigra tissue from postmortem brain of normal controls.

Parkinson's disease study 26 (BRAAK V-VI) / normal substantia nigra tissue

Relative Expression (log2-ratio):-2.4338703
Number of Samples:7 / 8
Experimental Parkinson's disease study 26 (BRAAK V-VI)
Substantia nigra biopsies derived postmortem from subject with sporadic Parkinson's disease BRAAK stage V-VI, age of onset > 45 years. Parkinson disease duration 17.7 years ± 6.7. The subjects had no history of cancer or concomitant disease of CNS. Mean age at death 78.5 (±8.5). Further neuropathological characteristics: median neurofibrillary tangle score (NFT) 1 (range 0-2); median amyloid-beta score A (range 0-C); mean neuronal cell density 2575 (± 530).
Control normal substantia nigra tissue
Substantia nigra biopsies derived postmortem from neurologically healthy age-matched subjects. Age at death 75.5 (±7.6). Neuropathological characteristics: BRAAK stage 0; median neurofibrillary tangle score (NFT) 1 (range 0-2); median amyloid-beta score 0 (range 0-B); mean neuronal cell density 6659 (± 960).

adrenal gland cancer study 5 (ACC) / normal adrenal cortex tissue

Relative Expression (log2-ratio):-2.4291487
Number of Samples:34 / 4
Experimental adrenal gland cancer study 5 (ACC)
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples.

adrenal gland cancer study 5 (ACA) / normal adrenal cortex tissue

Relative Expression (log2-ratio):-2.3217373
Number of Samples:58 / 4
Experimental adrenal gland cancer study 5 (ACA)
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical adenoma (ACA).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples.