TOP TEN perturbations for P10696 (Homo sapiens)

Organism: Homo sapiens
Gene: P10696
Selected probe(set): 210431_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P10696 (210431_at) across 5392 perturbations tested by GENEVESTIGATOR:

CH5183284 study 1 (HSC-39) / vehicle (DMSO) treated HSC-39 cell sample

Relative Expression (log2-ratio):1.8813181
Number of Samples:2 / 2
Experimental CH5183284 study 1 (HSC-39)
Human gastric cell line HSC-39 treated with 1 uM of FGFR inhibitor CH5183284 for 24 hours. ATC code:---
Control vehicle (DMSO) treated HSC-39 cell sample
Human gastric cell line HSC-39 treated with 0.1% DMSO for 24 hours.

colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; lung)

Relative Expression (log2-ratio):1.7208462
Number of Samples:2 / 5
Experimental colorectal cancer study 43 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control colorectal cancer study 43 (metastase; lung)
Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.

glioma study 17 ( small cell glioblastoma; unsorted) / non-tumor cortical tissue

Relative Expression (log2-ratio):-1.6426888
Number of Samples:2 / 4
Experimental glioma study 17 ( small cell glioblastoma; unsorted)
Brain cells isolated from high grade small cell glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation. Patients were 56 ? 3 years old males.
Control non-tumor cortical tissue
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses.

colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; liver)

Relative Expression (log2-ratio):1.5592232
Number of Samples:2 / 25
Experimental colorectal cancer study 43 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control colorectal cancer study 43 (metastase; liver)
Metastatic tumor tissue obtained from the liver of patients with primary colon adenocarcinoma.

AsPC-1 / BxPC-3

Relative Expression (log2-ratio):1.5499573
Number of Samples:3 / 3
Experimental AsPC-1
Human xenograft derived metastatic cancer cell line derived from mouse xenografts initiated with metastatic cells from the ascites derived from a 62 years old female Caucasian patient with pancreatic adenocarcinoma. Synonyms:AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 Cellosaurus code:
Control BxPC-3
Human pancreatic adenocarcinoma cell line derived from a 61 years old female patient. Synonyms:BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3 Cellosaurus code:

gastric cancer study 7 (mixed infiltrative adenocarcinoma) / gastric cancer study 7 (carcinoma, diffuse type)

Relative Expression (log2-ratio):1.4178753
Number of Samples:2 / 29
Experimental gastric cancer study 7 (mixed infiltrative adenocarcinoma)
Primary tumor tissue sample obtained from the gastrointestinal tract of patients with mixed infiltrative adenocarcinoma.
Control gastric cancer study 7 (carcinoma, diffuse type)
Primary tumor tissue sample obtained from the gastrointestinal tract of patients with carcinoma (diffuse type).

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.3912611
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

gastric cancer study 7 (mixed infiltrative adenocarcinoma) / gastric cancer study 7 (adenocarcinoma, NOS)

Relative Expression (log2-ratio):1.3145123
Number of Samples:2 / 84
Experimental gastric cancer study 7 (mixed infiltrative adenocarcinoma)
Primary tumor tissue sample obtained from the gastrointestinal tract of patients with mixed infiltrative adenocarcinoma.
Control gastric cancer study 7 (adenocarcinoma, NOS)
Primary tumor tissue sample obtained from the gastrointestinal tract of patients with adenocarcinoma, (NOS).

C. difficile study 1 (TcdB; 24h) / untreated HCT 8 cell sample

Relative Expression (log2-ratio):-1.3136139
Number of Samples:2 / 2
Experimental C. difficile study 1 (TcdB; 24h)
HCT 8 cells were treated with 100 ng/ml Toxin B (TcdB) isolated from Clostridium difficile strain VPI-10643 in RPMI-1640 supplemented with 10% heat-inactivated fetal bovine serum and 1mM sodium pyruvate for 24 hours.
Control untreated HCT 8 cell sample
Untreated HCT 8 cell sample cultured in RPMI-1640 supplemented with 10% heat-inactivated fetal bovine serum and 1mM sodium pyruvate for 24 hours.

tolbutamide study 8 (5500 uM; hES-Heps) / vehicle (DMSO) treated hES-Heps cell sample

Relative Expression (log2-ratio):1.3027296
Number of Samples:2 / 8
Experimental tolbutamide study 8 (5500 uM; hES-Heps)
hES-Heps cells exposed to 5500 uM tolbutamide (dissolved in 0.5% v/v DMSO) for 72 hours. Chemical was added at day 22 of differentiation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:,
Control vehicle (DMSO) treated hES-Heps cell sample
hES-Heps cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Vehicle was added at day 22 of differentiation.