TOP TEN perturbations for P22736 (Homo sapiens)

Organism: Homo sapiens
Gene: P22736
Selected probe(set): 202340_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P22736 (202340_x_at) across 5654 perturbations tested by GENEVESTIGATOR:

bladder cancer study 1 / normal bladder tissue

Relative Expression (log2-ratio):-4.614128
Number of Samples:3 / 3
Experimental bladder cancer study 1
Low grade superficial tumor samples.
Control normal bladder tissue
Normal bladder tissue.

A. fumigatus study 1 / uninfected immature dendritic cell sample

Relative Expression (log2-ratio):4.4185877
Number of Samples:2 / 2
Experimental A. fumigatus study 1
5 x 106 immature dendritic cells were cultivated together with 5 x 106 A. fumigatus germ tubes for 6h until isolation of total RNA.
Control uninfected immature dendritic cell sample
5 x 106 immature dendritic cells were cultivated without fungi.

T-helper activation study 1 (60min) / unstimulated helper T-cell sample

Relative Expression (log2-ratio):4.3373127
Number of Samples:2 / 2
Experimental T-helper activation study 1 (60min)
Alloantigen specific helper T-cells were stimulated for 60min with anti-CD3/anti-CD28/IL-2 (100U/ml). T-helper cells were sorted as CD4+ CD25- cells from peripheral blood of healthy donors.
Control unstimulated helper T-cell sample
Unstimulated alloantigen specific helper T-cell sample derived from sorted CD4+ CD25- cells from peripheral blood of healthy donors.

bladder cancer study 2 / normal bladder tissue

Relative Expression (log2-ratio):-4.233119
Number of Samples:3 / 3
Experimental bladder cancer study 2
High grade superficial tumors with an unclear clinical behavior.
Control normal bladder tissue
Normal bladder tissue.

T-helper activation study 1 (220min) / unstimulated helper T-cell sample

Relative Expression (log2-ratio):4.10186
Number of Samples:2 / 2
Experimental T-helper activation study 1 (220min)
Alloantigen specific helper T-cells were stimulated for 220min with anti-CD3/anti-CD28/IL-2 (100U/ml). T-helper cells were sorted as CD4+ CD25- cells from peripheral blood of healthy donors.
Control unstimulated helper T-cell sample
Unstimulated alloantigen specific helper T-cell sample derived from sorted CD4+ CD25- cells from peripheral blood of healthy donors.

T-helper activation study 1 (180min) / unstimulated helper T-cell sample

Relative Expression (log2-ratio):4.074198
Number of Samples:2 / 2
Experimental T-helper activation study 1 (180min)
Alloantigen specific helper T-cells were stimulated for 180min with anti-CD3/anti-CD28/IL-2 (100U/ml). T-helper cells were sorted as CD4+ CD25- cells from peripheral blood of healthy donors.
Control unstimulated helper T-cell sample
Unstimulated alloantigen specific helper T-cell sample derived from sorted CD4+ CD25- cells from peripheral blood of healthy donors.

T-helper activation study 1 (260min) / unstimulated helper T-cell sample

Relative Expression (log2-ratio):4.0686417
Number of Samples:2 / 2
Experimental T-helper activation study 1 (260min)
Alloantigen specific helper T-cells were stimulated for 260min with anti-CD3/anti-CD28/IL-2 (100U/ml). T-helper cells were sorted as CD4+ CD25- cells from peripheral blood of healthy donors.
Control unstimulated helper T-cell sample
Unstimulated alloantigen specific helper T-cell sample derived from sorted CD4+ CD25- cells from peripheral blood of healthy donors.

sapphyrin PCI-5002; ZnOAc2 study 1 / mannitol treated A549 cell sample

Relative Expression (log2-ratio):4.0569134
Number of Samples:3 / 3
Experimental sapphyrin PCI-5002; ZnOAc2 study 1
A549 human lung cancer cells were seeded 8 days. At 4 hours prior to RNA isolation, PCI-5002 (10 μM final concentration) + ZnOAc2 (25 μM final concentration) solution was added to the cultures. ATC code:---
Control mannitol treated A549 cell sample
A549 human lung cancer cells were seeded 8 days. At 4 hours prior to RNA isolation, 5% mannitol solution was added to the cultures.

T-helper activation study 1 (200min) / unstimulated helper T-cell sample

Relative Expression (log2-ratio):4.051735
Number of Samples:2 / 2
Experimental T-helper activation study 1 (200min)
Alloantigen specific helper T-cells were stimulated for 200min with anti-CD3/anti-CD28/IL-2 (100U/ml). T-helper cells were sorted as CD4+ CD25- cells from peripheral blood of healthy donors.
Control unstimulated helper T-cell sample
Unstimulated alloantigen specific helper T-cell sample derived from sorted CD4+ CD25- cells from peripheral blood of healthy donors.

heregulin / U0126 study 1 (late) / untreated MCF-7 cell sample

Relative Expression (log2-ratio):4.003907
Number of Samples:4 / 2
Experimental heregulin / U0126 study 1 (late)
MCF-7 human breast cancer cells were incubated for 30, 45, 60 and 90min with both, growth hormone heregulin (HRG) and the selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, U0126 (1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene).
Control untreated MCF-7 cell sample
Untreated MCF-7 human breast cancer cells.