TOP TEN perturbations for P43628 (Homo sapiens)

Organism: Homo sapiens
Gene: P43628
Selected probe(set): 208179_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P43628 (208179_x_at) across 5392 perturbations tested by GENEVESTIGATOR:

ovulation study 3 / proliferative phase endometrium tissue

Relative Expression (log2-ratio):1.8720198
Number of Samples:5 / 4
Experimental ovulation study 3
Late secretory phase (LSE) endometrium tissue.
Control proliferative phase endometrium tissue
Proliferative phase (PE) endometrium tissue.

Jurkat-PSIP1 KD / Jurkat

Relative Expression (log2-ratio):-1.2789698
Number of Samples:3 / 3
Experimental Jurkat-PSIP1 KD
Jurkat cells stably transfected with shRNA constructs (si1340) against LEDGF transcript (PSIP1 gene). Jurkat cells are human relapse cancer cell line derived from the peripheral blood of a patient with acute lymphoblastic leukemia. Parental cell line:: Jurkat Synonyms:Jurkat-siJK2
Control Jurkat
Human relapse cancer cell line derived from the peripheral blood of a patient with acute lymphoblastic leukemia. Synonyms:JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 Cellosaurus code:

exercise study 45 (normal; exercise recovery; 3h) / exercise study 45 (normal; post-exercise)

Relative Expression (log2-ratio):-1.2638226
Number of Samples:11 / 11
Experimental exercise study 45 (normal; exercise recovery; 3h)
Normal peripheral blood mononuclear cell samples obtained from healthy sedentary veterans (33-52 years old) 3 hours after the exercise bout. Subjects participated in symptom-limited maximum graded exercise stress test on a bicycle ergometer. It included pedaling at a power output of 60 watts for 2 minutes and increasing this every 2 minutes, by 30 watts until one of the maximal test criteria were met, these were a plateau in maximal oxygen consumption, a respiratory exchange ratio greater than 1.15 or the subject stopped the test despite vocal urging from the staff. The subjects started the exercise 30 min after the breakfast (contents uniform for all participants). Other parameters: mean age (range) 43.8 (33-52) years, body mass index BMI (range) 26.7 (18.8-31.0) kg/m2, 4 subjects were African American, 4 Hispanic and 3 White.
Control exercise study 45 (normal; post-exercise)
Normal peripheral blood mononuclear cell samples obtained from healthy sedentary veterans (33-52 years old) immediately after the exercise bout. Subjects participated in symptom-limited maximum graded exercise stress test on a bicycle ergometer. It included pedaling at a power output of 60 watts for 2 minutes and increasing this every 2 minutes, by 30 watts until one of the maximal test criteria were met (a plateau in maximal oxygen consumption, a respiratory exchange ratio greater than 1.15 or the subject stopped the test despite vocal urging from the staff). The subjects started the exercise 30 min after the breakfast (contents uniform for all participants). Other parameters: mean age (range) 43.8 (33-52) years, body mass index BMI (range) 26.7 (18.8-31.0) kg/m2, 4 subjects were African American, 4 Hispanic and 3 White.

ALL study 2 (15d) / ALL study 2 (0d)

Relative Expression (log2-ratio):1.2184706
Number of Samples:45 / 129
Experimental ALL study 2 (15d)
Bone marrow samples from children with de novo acute lymphoblastic leukemia. Samples were taken 15 days after remission-induction therapy (RIT).
Control ALL study 2 (0d)
Bone marrow samples from children with de novo acute lymphoblastic leukemia. Samples were taken before remission-induction therapy (RIT).

exercise study 45 (normal; post-exercise) / exercise study 45 (normal; pre-exercise)

Relative Expression (log2-ratio):1.1233435
Number of Samples:11 / 11
Experimental exercise study 45 (normal; post-exercise)
Normal peripheral blood mononuclear cell samples obtained from healthy sedentary veterans (33-52 years old) immediately after the exercise bout. Subjects participated in symptom-limited maximum graded exercise stress test on a bicycle ergometer. It included pedaling at a power output of 60 watts for 2 minutes and increasing this every 2 minutes, by 30 watts until one of the maximal test criteria were met (a plateau in maximal oxygen consumption, a respiratory exchange ratio greater than 1.15 or the subject stopped the test despite vocal urging from the staff). The subjects started the exercise 30 min after the breakfast (contents uniform for all participants). Other parameters: mean age (range) 43.8 (33-52) years, body mass index BMI (range) 26.7 (18.8-31.0) kg/m2, 4 subjects were African American, 4 Hispanic and 3 White.
Control exercise study 45 (normal; pre-exercise)
Normal peripheral blood mononuclear cell samples obtained from healthy sedentary veterans (33-52 years old) before exercise. The samples were taken 30 min after the breakfast (contents uniform for all participants). Other parameters: mean age (range) 43.8 (33-52) years, body mass index BMI (range) 26.7 (18.8-31.0) kg/m2, 4 subjects were African American, 4 Hispanic and 3 White.

rheumatoid arthritis study 37 (blood; post-treatment; TCZ; responder) / rheumatoid arthritis study 37 (blood; naive)

Relative Expression (log2-ratio):1.1149683
Number of Samples:32 / 18
Experimental rheumatoid arthritis study 37 (blood; post-treatment; TCZ; responder)
Blood samples derived from patients with rheumatoid arthritis (RA) after treatment with tocilizumab (TCZ) and classified as responder. Samples were obtained at 24 weeks after the initiation of drug treatment. Patients who displayed a good response on drug treatment were classified as good responders by European League Against Rheumatism (EULAR) response criteria at 24 weeks after the initiation of drug treatment. ATC code:
Control rheumatoid arthritis study 37 (blood; naive)
Blood samples derived from drug-naive patients with rheumatoid arthritis (RA). Drug-naive patients were not being treated with moderate-to-high doses of corticosteroids, immunosuppressants, or biological agents when entered in to the study.

rheumatoid arthritis study 37 (blood; post-treatment; MTX; responder) / rheumatoid arthritis study 37 (blood; naive)

Relative Expression (log2-ratio):1.0900459
Number of Samples:37 / 18
Experimental rheumatoid arthritis study 37 (blood; post-treatment; MTX; responder)
Blood samples derived from patients with rheumatoid arthritis (RA) after treatment with methotrexate (MTX) and classified as responder. Samples were obtained at 24 weeks after the initiation of drug treatment. Patients who displayed a good response on drug treatment were classified as good responders by European League Against Rheumatism (EULAR) response criteria at 24 weeks after the initiation of drug treatment. Patients characteristics: age 58.70?10.63 year; 2 males and 8 females; RF positive 7 (70.0%); ACPA positive 7 (70.0%); CRP 0.99?1.04 mg/dl; ESR 50.30?32.40 mm/hr; DAS28-CRP 4.15?0.75; DAS28-ESR 4.97?0.76; SDAI 18.96?7.47; CDAI 17.97?7.42; HAQ-DI 0.85?0.61; TJC28 5.20?3.46; SJC28 5.00?3.30; Pain, VAS 41.10?25.24; Physician GA, VAS 29.40 ?11.50 mm; Subject GA, VAS 48.30?15.33 mm. ATC code: ATC code:
Control rheumatoid arthritis study 37 (blood; naive)
Blood samples derived from drug-naive patients with rheumatoid arthritis (RA). Drug-naive patients were not being treated with moderate-to-high doses of corticosteroids, immunosuppressants, or biological agents when entered in to the study.

polyarticular JIA study 6 / juvenile enthesitis related arthritis study 2 (ERA)

Relative Expression (log2-ratio):-1.052043
Number of Samples:14 / 3
Experimental polyarticular JIA study 6
Peripheral blood mononuclear cell (PBMC) samples from children with rheumatoid factor negative polyarthritis (RF- polyarthritis/RF- polyarticular JIA).
Control juvenile enthesitis related arthritis study 2 (ERA)
Peripheral blood mononuclear cell (PBMC) samples from children with enthesitis related arthritis (ERA).

pediatric meningococcal sepsis study 1 (late) / normal PBMC (CD14-) sample

Relative Expression (log2-ratio):-1.0344934
Number of Samples:7 / 4
Experimental pediatric meningococcal sepsis study 1 (late)
CD14 negative cell fraction (PBMC CD14-) isolated from peripheral blood mononuclear cells, which is enriched for B- and T-cells. Peripheral blood mononuclear cells were derived from whole blood drawn from children with meningococcal sepsis 24 or 72 hours after admission to the pediatric intensive care unit.
Control normal PBMC (CD14-) sample
CD14 negative cell fraction (PBMC CD14-) isolated from peripheral blood mononuclear cells, which is enriched for B- and T-cells. Peripheral blood mononuclear cells were derived from whole blood drawn from matched control subjects.

rheumatoid arthritis study 37 (blood; post-treatment; TCZ; non-responder) / rheumatoid arthritis study 37 (blood; naive)

Relative Expression (log2-ratio):1.0263252
Number of Samples:4 / 18
Experimental rheumatoid arthritis study 37 (blood; post-treatment; TCZ; non-responder)
Blood samples derived from patients with rheumatoid arthritis (RA) after treatment with tocilizumab (TCZ) and classified as non-responder. Samples were obtained at 24 weeks after the initiation of drug treatment. Patients who did not displayed a good response on drug treatment were classified as inadequate responders (non-responders) by European League Against Rheumatism (EULAR) response criteria at 24 weeks after the initiation of drug treatment. ATC code:
Control rheumatoid arthritis study 37 (blood; naive)
Blood samples derived from drug-naive patients with rheumatoid arthritis (RA). Drug-naive patients were not being treated with moderate-to-high doses of corticosteroids, immunosuppressants, or biological agents when entered in to the study.