TOP TEN perturbations for P48553 (Homo sapiens)

Organism: Homo sapiens
Gene: P48553
Selected probe(set): 1555446_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P48553 (1555446_s_at) across 5638 perturbations tested by GENEVESTIGATOR:

kidney transplantation study 15 (8 week) / normal monocyte (CD14+) sample

Relative Expression (log2-ratio):2.7389746
Number of Samples:2 / 5
Experimental kidney transplantation study 15 (8 week)
CD14+ monocyte samples derived from kidney transplant patients 8 weeks post-transplantation. Samples were collected 8 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal monocyte (CD14+) sample
CD14+ monocyte samples derived from healthy control subjects.

kidney transplantation study 15 (4 week) / normal monocyte (CD14+) sample

Relative Expression (log2-ratio):2.4644108
Number of Samples:2 / 5
Experimental kidney transplantation study 15 (4 week)
CD14+ monocyte samples derived from kidney transplant patients 4 weeks post-transplantation. Samples were collected 4 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal monocyte (CD14+) sample
CD14+ monocyte samples derived from healthy control subjects.

sangivamycin study 1 / untreated MCF-7 cell sample

Relative Expression (log2-ratio):2.3820143
Number of Samples:2 / 2
Experimental sangivamycin study 1
MCF7 cells treated with 2uM sangivamycin for 24 hours. ATC code:---
Control untreated MCF-7 cell sample
MCF-7 cells untreated.

kidney transplantation study 12 (4 week) / normal T-cell (CD4+) sample

Relative Expression (log2-ratio):2.3428955
Number of Samples:2 / 5
Experimental kidney transplantation study 12 (4 week)
CD4+ T-cell samples derived from kidney transplant patients 4 weeks post-transplantation. Samples were collected 4 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal T-cell (CD4+) sample
CD4+ T-cell samples derived from healthy control subjects.

Langerhans cell histiocytosis study 2 (multisystem) / Langerhans cell histiocytosis study 2 (unifocal)

Relative Expression (log2-ratio):-2.3165102
Number of Samples:2 / 8
Experimental Langerhans cell histiocytosis study 2 (multisystem)
Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal, multisystem (disseminated) disease. Both patients received chemotherapy. Sites of LCH lesions: subj.ID:1 (skin, lungs, multiple skull, mastoid, gingiva), subj.ID:13 (mandible, skull, vertebrae, recurrent orbit, liver, spleen, pituitary gland).
Control Langerhans cell histiocytosis study 2 (unifocal)
Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with unifocal, single system disease (bone lesion).

NGFR depletion study 1 / normal SW-480 cell sample

Relative Expression (log2-ratio):2.1646395
Number of Samples:6 / 3
Experimental NGFR depletion study 1
RNAi-mediated gene knockdown of NGFR in colorectal cancer cell line SW-480.
Control normal SW-480 cell sample
Non-transduced SW-480 colorectal cell line sample.

lung adenocarcinoma study 9 (metastase; lymph node) / lung adenocarcinoma study 9 (metastase; brain)

Relative Expression (log2-ratio):2.1460247
Number of Samples:3 / 6
Experimental lung adenocarcinoma study 9 (metastase; lymph node)
Metastatic tumor tissue obtained from the lymph node of patients with primary lung adenocarcinoma.
Control lung adenocarcinoma study 9 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary lung adenocarcinoma.

skin squamous cell carcinoma study 6 / normal skin tissue

Relative Expression (log2-ratio):2.0258188
Number of Samples:4 / 64
Experimental skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).
Control normal skin tissue
Normal skin samples from healthy donors.

diclofenac study 7 (24h) / vehicle (PBS) treated HepG2 cell sample

Relative Expression (log2-ratio):-1.9975643
Number of Samples:3 / 3
Experimental diclofenac study 7 (24h)
HepG2 cells exposed to 100μM diclofenac in PBS solvent for 24 hours. ATC code:, ,
Control vehicle (PBS) treated HepG2 cell sample
HepG2 cells exposed to 0.5% PBS solvent for 24 hours.

paracetamol (acetaminophen) study 11 (24h) / vehicle (PBS) treated HepG2 cell sample

Relative Expression (log2-ratio):-1.9402122
Number of Samples:3 / 3
Experimental paracetamol (acetaminophen) study 11 (24h)
HepG2 cells exposed to 100μM acetaminophen (paracetamol) in PBS solvent for 24 hours. ATC code:
Control vehicle (PBS) treated HepG2 cell sample
HepG2 cells exposed to 0.5% PBS solvent for 24 hours.