TOP TEN perturbations for P54198 (Homo sapiens)

Organism: Homo sapiens
Gene: P54198
Selected probe(set): 217427_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P54198 (217427_s_at) across 5392 perturbations tested by GENEVESTIGATOR:

peptidoglycan study 1 / mock treated neonatal neutrophils

Relative Expression (log2-ratio):-3.0144806
Number of Samples:3 / 3
Experimental peptidoglycan study 1
Healthy neonatal neutrophils with ? 99% purity isolated from cord blood samples collected after normal, full-term, vaginal delivery treated with peptidoglycan isolated from S. aureus (10 ug/ml) for 4 hours.
Control mock treated neonatal neutrophils
Healthy neonatal neutrophils with ? 99% purity isolated from cord blood samples collected after normal, full-term, vaginal delivery mock treated for 4 hours.

F. tularensis study 1 (tularensis Schu S4) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):-2.6594448
Number of Samples:4 / 6
Experimental F. tularensis study 1 (tularensis Schu S4)
Peripheral blood monocytes infected with the Schu S4 isolate of Francisella tularensis (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

diabetes type 2 study 14 (diabetic) / non-diabetic omental adipose tissue

Relative Expression (log2-ratio):-2.6556787
Number of Samples:11 / 6
Experimental diabetes type 2 study 14 (diabetic)
Omental adipose tissue of morbidly obese (BMI ? 40 kg/m2) African-American individuals with type 2 diabetes.
Control non-diabetic omental adipose tissue
Omental adipose tissue of morbidly obese (BMI ? 40 kg/m2) African-American individuals without type 2 diabetes.

metformin study 6 (1000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.561347
Number of Samples:2 / 2
Experimental metformin study 6 (1000uM)
Hepatocytes treated with compound: metformin (1000uM; CHEMBL1431) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

R547 study 1 (24h) / vehicle (DMSO) treated DU145 cell sample

Relative Expression (log2-ratio):-2.536252
Number of Samples:2 / 4
Experimental R547 study 1 (24h)
Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 24 hours at a 3xIC90 concentration of 5.1 ?mol/L. ATC code:---
Control vehicle (DMSO) treated DU145 cell sample
Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 24 hours.

interferon-alpha-kinoid study 2 (240ug; 112d) / untreated whole blood sample

Relative Expression (log2-ratio):-2.486495
Number of Samples:3 / 43
Experimental interferon-alpha-kinoid study 2 (240ug; 112d)
Whole blood samples of patients with systemic lupus erythematosus after treatment with interferon-alpha-kinoid (INF-K; inactivated IFNa coupled keyhole limpet hemocyanin as carrier). Patients had 4 doses of 240ug INK-K at day 0, 7, 58 and 84. Sample was taken 112 days after the first application of TNF-K. ATC code:---
Control untreated whole blood sample
Whole blood samples from healthy volunteers.

azathioprine study 7 (250uM) / vehicle (DMSO) treated HepG2 sample

Relative Expression (log2-ratio):-2.3769855
Number of Samples:3 / 21
Experimental azathioprine study 7 (250uM)
HepG2 cells treated with compound: azathioprine (250uM; CAS no.:446-86-6) for 24 hours. Azathioprine is hepatotoxic and may cause cholestasis. HepG2 cells were treated with the IC20 concentration measured after 72 hours. ATC code:
Control vehicle (DMSO) treated HepG2 sample
HepG2 cells treated with DMSO (0.5% v/v) as solvent control for 24 hours.

4-acetylaminofluorene study 1 (48h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):-2.3565922
Number of Samples:3 / 19
Experimental 4-acetylaminofluorene study 1 (48h)
HepG2 cells exposed to 100nM 4-acetylaminofluorene in DMSO solvent for 48 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 48 hours.

influenza virus study 10 (A/H5N2) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):2.3547716
Number of Samples:3 / 3
Experimental influenza virus study 10 (A/H5N2)
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F189/07/2004(H5N2). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.

phenobarbital study 2 (10000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.3008661
Number of Samples:2 / 2
Experimental phenobarbital study 2 (10000uM)
Hepatocytes treated with compound: phenobarbital (10000uM; CHEMBL40) for 8 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 8 hours.