TOP TEN perturbations for P62273 (Homo sapiens)

Organism: Homo sapiens
Gene: P62273
Selected probe(set): 201094_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of P62273 (201094_at) across 5392 perturbations tested by GENEVESTIGATOR:

kidney transplantation study 16 (2 week) / normal natural killer cell (CD56+) sample

Relative Expression (log2-ratio):-2.4571714
Number of Samples:3 / 3
Experimental kidney transplantation study 16 (2 week)
CD56+ natural killer cell samples derived from kidney transplant patients 2 weeks post-transplantation. Samples were collected 2 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal natural killer cell (CD56+) sample
CD56+ natural killer cell samples derived from healthy control subjects.

interferon-alpha-kinoid study 1 (240ug; 112d) / untreated whole blood sample

Relative Expression (log2-ratio):-1.7351475
Number of Samples:2 / 43
Experimental interferon-alpha-kinoid study 1 (240ug; 112d)
Whole blood samples of patients with systemic lupus erythematosus after treatment with interferon-alpha-kinoid (INF-K; inactivated IFNa coupled keyhole limpet hemocyanin as carrier). Patients had 3 doses of 240ug INK-K at day 0, 7 and 58. Sample was taken 112 days after the first application of TNF-K. ATC code:---
Control untreated whole blood sample
Whole blood samples from healthy volunteers.

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):1.3911533
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

sickle cell disease study 1 / normal platelet sample

Relative Expression (log2-ratio):-1.2638378
Number of Samples:17 / 11
Experimental sickle cell disease study 1
Platelets isolated from peripheral blood of patients with sickle cell disease.
Control normal platelet sample
Platelets isolated from peripheral blood of healthy control volunteers.

propiconazole study 1 (high) / DMSO treated hepatocyte sample

Relative Expression (log2-ratio):1.2443562
Number of Samples:4 / 4
Experimental propiconazole study 1 (high)
Primary hepatocytes were exposed to medium containing 100uM propiconazole (high dose) for 72h. ATC code:---
Control DMSO treated hepatocyte sample
Primary hepatocytes cultured for 72h in medium containing DMSO 0.1%.

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):1.2001476
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

Xq12?q13.3 duplication syndrome study 1 / normal lymphoblastoid cell line sample

Relative Expression (log2-ratio):-1.161869
Number of Samples:2 / 13
Experimental Xq12?q13.3 duplication syndrome study 1
Lymphoblastoid cell line samples from two brothers with Xq12?q13.3 duplication. The patients are affected by severe autism and global developmental delay with multiorgan involvement.
Control normal lymphoblastoid cell line sample
Lymphoblastoid cell line samples from healthy subjects.

interferon-alpha-kinoid study 1 (30ug; 112d) / untreated whole blood sample

Relative Expression (log2-ratio):1.1541348
Number of Samples:3 / 43
Experimental interferon-alpha-kinoid study 1 (30ug; 112d)
Whole blood samples of patients with systemic lupus erythematosus after treatment with interferon-alpha-kinoid (INF-K; inactivated IFNa coupled keyhole limpet hemocyanin as carrier). Patients had 3 doses of 30ug INK-K at day 0, 7 and 58. Sample was taken 112 days after the first application of TNF-K. ATC code:---
Control untreated whole blood sample
Whole blood samples from healthy volunteers.

interferon-alpha-kinoid study 2 (120ug; 168d) / untreated whole blood sample

Relative Expression (log2-ratio):1.1515541
Number of Samples:2 / 43
Experimental interferon-alpha-kinoid study 2 (120ug; 168d)
Whole blood samples of patients with systemic lupus erythematosus after treatment with interferon-alpha-kinoid (INF-K; inactivated IFNa coupled keyhole limpet hemocyanin as carrier). Patients had 4 doses of 120ug INK-K at day 0, 7, 58 and 84. Sample was taken 168 days after the first application of TNF-K. ATC code:---
Control untreated whole blood sample
Whole blood samples from healthy volunteers.

hypoxia study 7 (high altitude) / hypoxia study 7 (sea level)

Relative Expression (log2-ratio):1.1333008
Number of Samples:96 / 98
Experimental hypoxia study 7 (high altitude)
Human peripheral monunuclear blood cells taken from the blood of healthy volunteers after acute elevation to high altitude at the South Pole McMurdo station on the third day.
Control hypoxia study 7 (sea level)
Human peripheral monunuclear blood cells taken from the blood of healthy volunteers at sea level at the South Pole McMurdo station on the third day.