TOP TEN perturbations for Q15022 (Homo sapiens)

Organism: Homo sapiens
Gene: Q15022
Selected probe(set): 212287_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q15022 (212287_at) across 5654 perturbations tested by GENEVESTIGATOR:

colorectal adenoma study 2 / normal colon tissue

Relative Expression (log2-ratio):-2.4918613
Number of Samples:5 / 6
Experimental colorectal adenoma study 2
Laser microdissected human adenoma sample.
Control normal colon tissue
Laser microdissected human colonic epithelial cells sample.

zalypsis study 2 / untreated OPM1 cell sample

Relative Expression (log2-ratio):-2.1718063
Number of Samples:2 / 2
Experimental zalypsis study 2
OPM1 multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:---
Control untreated OPM1 cell sample
OPM1 multiple myeloma cells untreated.

R547 study 1 (24h) / vehicle (DMSO) treated DU145 cell sample

Relative Expression (log2-ratio):-2.0460415
Number of Samples:2 / 4
Experimental R547 study 1 (24h)
Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 24 hours at a 3xIC90 concentration of 5.1 μmol/L. ATC code:---
Control vehicle (DMSO) treated DU145 cell sample
Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 24 hours.

ovarian tumor study 17 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.9892578
Number of Samples:9 / 10
Experimental ovarian tumor study 17
Human epithelial tumor cell samples from the ovary of patients with primary clear cell carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):-1.68468
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):-1.6132822
Number of Samples:4 / 2
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal fetal kidney tissue samples.

Huntington's disease study 11 / normal dermal fibroblast cell sample

Relative Expression (log2-ratio):1.6125555
Number of Samples:6 / 3
Experimental Huntington's disease study 11
Primary dermal fibroblast cell samples isolated from male subjects with Huntington's disease (HD). Subjects with inflammatory or infective conditions were excluded. One sample of HD fibroblast cells (ID:GM04799) was purchased from the Coriell Cell Repository. Cells were cultured in MEM medium supplemented with 10% FBS and antibiotics. Cells were used at passage 8-10 and harvested by trypsin treatment.
Control normal dermal fibroblast cell sample
Primary dermal fibroblast cell samples isolated from healthy male subjects. Cells were cultured in MEM medium supplemented with 10% FBS and antibiotics. Cells were used at passage 8-10 and harvested by trypsin treatment.

TNF-ɑ; IL-1b; IL-6; PGE2 study 1 / control antibody treated immature dendritic cell sample

Relative Expression (log2-ratio):1.6094227
Number of Samples:4 / 5
Experimental TNF-ɑ; IL-1b; IL-6; PGE2 study 1
Immature dendritic cells (DCs) treated with inflammatory cytokine cocktail (10 ng/ml IL-1b, 1,000 U/ml IL-6, 10 ng/ml TNF-ɑ, 1μg/ml prostaglandin E2) for 24 h.
Control control antibody treated immature dendritic cell sample
Immature dendritic cells (DCs) treated with isotype control antibody (10 - 20μg/ml mouse IgG1 isotype) for 24 h.

precursor-B-ALL study 3 (hyperdiploid) / precursor-B-ALL study 3 (BCR-ABL)

Relative Expression (log2-ratio):1.4583254
Number of Samples:17 / 4
Experimental precursor-B-ALL study 3 (hyperdiploid)
Peripheral blood and bone marrow samples of pediatric patients with precursor B-ALL (hyperdiploidy). Patients were part of the Nordic Society Of Pediatric Hematology And Oncology Group (NOPHO).
Control precursor-B-ALL study 3 (BCR-ABL)
Peripheral blood and bone marrow samples of pediatric patients with precursor B-ALL [t(9;22)(q34;q11.2)/BCR-ABL1]. Patients were part of the Nordic Society Of Pediatric Hematology And Oncology Group (NOPHO).

human rhinovirus study 2 / mock infected bronchial epithelial cell sample

Relative Expression (log2-ratio):-1.447052
Number of Samples:6 / 6
Experimental human rhinovirus study 2
Human primary bronchial epithelial cells from normal subjects, infected with purified and concentrated minor group human rhinovirus (HRV) serotype 1A at multiplicity of infection of 10 plaque forming units (pfu) per cell. Cells were lysed 16 hours post infection.
Control mock infected bronchial epithelial cell sample
Human primary bronchial epithelial cells from normal subjects. Cells were mock-infected with growth medium alone for 16 hours.