TOP TEN perturbations for Q496J9 (Homo sapiens)

Organism: Homo sapiens
Gene: Q496J9
Selected probe(set): 216086_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q496J9 (216086_at) across 5880 perturbations tested by GENEVESTIGATOR:

HIV-associated neurocognitive disorder study 9 (HIVE) / HIV-associated dementia study 1

Relative Expression (log2-ratio):-4.7014
Number of Samples:5 / 7
Experimental HIV-associated neurocognitive disorder study 9 (HIVE)
Postmortem cerebral white matter tissue from HIV-1-infected patients with substantial HIV-associated neurocognitive impairment (HAND). Patients had no encephalitis (HIVE) or other neuropathological defect.
Control HIV-associated dementia study 1
Postmortem basal ganglia tissue from HIV-1-infected patients with substantial HIV-associated neurocognitive impairment (HAND). Patients had no encephalitis (HIVE) or other neuropathological defect.

16,16-dimethylprostaglandin E2 study 3 (2h; 10uM; 37°C) / vehicle (DMSO) treated hematopoietic stem cell sample (2h; 37°C)

Relative Expression (log2-ratio):4.575981
Number of Samples:7 / 7
Experimental 16,16-dimethylprostaglandin E2 study 3 (2h; 10uM; 37°C)
Human CD34+ hematopoietic stem cells treated with 10 uM 16,16-dimethylprostaglandin E2 (dmPGE2) for 2 hours at 37°C. The cells were isolated from umbilical cord blood. ATC code:---
Control vehicle (DMSO) treated hematopoietic stem cell sample (2h; 37°C)
Human CD34+ hematopoietic stem cells treated with DMSO for 2 hours at 37°C. The cells were isolated from umbilical cord blood.

Parkinson's disease study 6 / normal pars reticulata tissue

Relative Expression (log2-ratio):-4.571288
Number of Samples:3 / 4
Experimental Parkinson's disease study 6
Pars reticulata tissue from patients with Parkinson's disease.
Control normal pars reticulata tissue
Normal pars reticulata tissue.

HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)

Relative Expression (log2-ratio):3.7553596
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).

null cell adenoma study 1 / gonadotroph adenoma study 1

Relative Expression (log2-ratio):-3.6002283
Number of Samples:2 / 7
Experimental null cell adenoma study 1
Null cell adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined by gonadotropic staining for FSH, LH, or alpha subunit in less than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005.
Control gonadotroph adenoma study 1
Gonadotroph adenoma biopsy samples recovered during transsphenoidal surgery. The tumors were defined as demonstrating positive immunostaining for FSH, LH, or alpha subunit in greater than 5-10% of cells. Samples were scanned between 04/6/2004 - 15/4/2005.

ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; metastatic) / ovarian tumor study 30 (PDX; carcinoma, NOS; metastatic)

Relative Expression (log2-ratio):-3.594501
Number of Samples:8 / 2
Experimental ovarian tumor study 30 (PDX; serous cystadenocarcinoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary serous cystadenocarcinoma, NOS of the ovary (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.
Control ovarian tumor study 30 (PDX; carcinoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary carcinoma, NOS of the ovary (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.

zalypsis study 1 / untreated MM1S cell sample

Relative Expression (log2-ratio):-3.5363255
Number of Samples:2 / 2
Experimental zalypsis study 1
MM1S multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:---
Control untreated MM1S cell sample
MM1S multiple myeloma cells untreated.

small cell lung cancer study 4 (XCL from PDX) / small cell lung cancer study 4 (XCL from CDX)

Relative Expression (log2-ratio):3.4398184
Number of Samples:3 / 11
Experimental small cell lung cancer study 4 (XCL from PDX)
Xenograft-derived cell lines (XCL) established from a small cell lung carcinoma (SCLC) patient derived xenografts (PDX). The discarded tissue from three chemo-naive patients (LX22; LX33 and LX35) was obtained during bronchoscopy and used to generate a xenograft. Aseptically resuspended tumour cells were injected s.c. in the flanks of nonobese diabetic/severe combined immunodeficient mice. The mice were sacrificed when the P0 tumors reached 1cm in diameter. Obtained cells were used for conventional cell culture cultivation.
Control small cell lung cancer study 4 (XCL from CDX)
Xenograft-derived cell lines (XCL) established from a small cell lung carcinoma (SCLC) publicly available cell lines derived xenografts (CDX derived cell lines). Xenografts were grown in the flanks of a nude mice. Obtained cells were cultivated under conventional tissue culture conditions.

TC-71 / TC-32

Relative Expression (log2-ratio):-3.2961473
Number of Samples:6 / 6
Experimental TC-71
Human primary cancer cell line derived from the humerus of a patient with Ewing sarcoma. Synonyms:TC71; GM11654 Cellosaurus code:
Control TC-32
Human primary cancer cell line derived from the unspecified origin of a patient with Ewing’s sarcoma. Synonyms:TC32 Cellosaurus code:

HIV-associated neurocognitive disorder study 7 (normal) / normal genu sample

Relative Expression (log2-ratio):3.290907
Number of Samples:2 / 8
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control normal genu sample
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from healthy subjects.