TOP TEN perturbations for Q5T5C0 (Homo sapiens)

Organism: Homo sapiens
Gene: Q5T5C0
Selected probe(set): 235227_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q5T5C0 (235227_at) across 5610 perturbations tested by GENEVESTIGATOR:

glioma study 5 / non-tumor brain tissue

Relative Expression (log2-ratio):-3.791317
Number of Samples:12 / 9
Experimental glioma study 5
Primary tumor tissue sample from the supratentorial brain of pediatric patients with glioblastoma multiformae.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

atypical teratoid/rhabdoid tumor study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):-3.7689571
Number of Samples:20 / 9
Experimental atypical teratoid/rhabdoid tumor study 1
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

brain tumor study 1 (ependymoma) / normal brain tissue

Relative Expression (log2-ratio):-3.5539227
Number of Samples:46 / 12
Experimental brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):-3.467987
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

brain tumor study 1 (glioblastoma) / normal brain tissue

Relative Expression (log2-ratio):-3.2866993
Number of Samples:34 / 12
Experimental brain tumor study 1 (glioblastoma)
Primary tumor tissue sample from the brain of patients with glioblastoma multiformae.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

brain tumor study 1 (pilocytic astrocytoma) / normal brain tissue

Relative Expression (log2-ratio):-3.2201653
Number of Samples:15 / 12
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

T-cell isolation study 11 / T-cell isolation study 6

Relative Expression (log2-ratio):-2.9959965
Number of Samples:2 / 2
Experimental T-cell isolation study 11
CD4+ resting memory T-cell were isolated from peripheral blood buffy coat of healthy donors after storage for 24 hours at 20°C. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population.
Control T-cell isolation study 6
CD4+ resting memory T-cell were isolated from whole peripheral blood of healthy donors with no delay. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population.

glioma study 3 / non-tumor brain tissue

Relative Expression (log2-ratio):-2.832737
Number of Samples:81 / 23
Experimental glioma study 3
Primary tumor tissue sample from the brain of patients with glioblastoma multiformae.
Control non-tumor brain tissue
Brain tissue samples from patients with epilepsy and without any manifested brain cancer.

HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)

Relative Expression (log2-ratio):2.6633568
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).

TGF-ß3 study 1 (early) / BMP-2 study 2 (early)

Relative Expression (log2-ratio):2.5797462
Number of Samples:2 / 3
Experimental TGF-ß3 study 1 (early)
Cultured mesenchymal stem cells from human bone marrow aspirates of healthy donors. Cells were stimulated with 10ng/ml of recombinant TGF-ß3 for 1 day. (Warning: Experiment with gender bias).
Control BMP-2 study 2 (early)
Cultured mesenchymal stem cells from human bone marrow aspirates of healthy donors. Cells were stimulated with 100ng/ml of recombinant BMP-2 for 1 day. (Warning: Experiment with gender bias).