TOP TEN perturbations for Q5VZB9 (Homo sapiens)

Organism: Homo sapiens
Gene: Q5VZB9
Selected probe(set): 244725_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q5VZB9 (244725_at) across 5392 perturbations tested by GENEVESTIGATOR:

atopic dermatitis study 21 (lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):1.6181688
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (lesional; whole skin)
Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

engineered skin substitute study 1 (intermediate) / engineered skin substitute study 1 (early)

Relative Expression (log2-ratio):-1.6097918
Number of Samples:3 / 2
Experimental engineered skin substitute study 1 (intermediate)
Human skin substitutes tissue samples collected after 7 days in culture.
Control engineered skin substitute study 1 (early)
Human skin substitutes tissue samples collected after 3 days in culture.

influenza virus study 9 (A/H9N2) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):-1.5871906
Number of Samples:3 / 3
Experimental influenza virus study 9 (A/H9N2)
Human carcinoma cell line A549 infected with influenza A virus subtype A/Duck/Malaysia/01 (H9N2). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.

engineered skin substitute study 1 (late) / engineered skin substitute study 1 (early)

Relative Expression (log2-ratio):-1.4886808
Number of Samples:3 / 2
Experimental engineered skin substitute study 1 (late)
Human skin substitutes tissue samples collected after 14 days in culture.
Control engineered skin substitute study 1 (early)
Human skin substitutes tissue samples collected after 3 days in culture.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.469552
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

normal skeletal muscle tissue (pre-training; active) / normal skeletal muscle tissue (pre-training; sedentary)

Relative Expression (log2-ratio):-1.3892212
Number of Samples:17 / 24
Experimental normal skeletal muscle tissue (pre-training; active)
Vastus lateralis muscle tissue biopsy samples from 17 young healthy active Caucasian men. Resting skeletal muscle biopsies were taken before the endurance training program. Average parameters of patients were: age=29?6 y, height=1.82?0.5 m, body mass=81.8?9 kg, VO2max=4.1?0.5 L.min-1.
Control normal skeletal muscle tissue (pre-training; sedentary)
Vastus lateralis muscle tissue biopsy samples from 24 young sedentary healthy Caucasian men. Resting skeletal muscle biopsies were taken before the endurance training program. Average parameters of patients were: age=23?1 y, height=1.82?0.02 m, body mass=78.6?2.7 kg, VO2max=3.71?0.55 L.min-1.

influenza virus study 11 (A/H5N3) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):-1.2981234
Number of Samples:3 / 3
Experimental influenza virus study 11 (A/H5N3)
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F119/3/1997(H5N3). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.

atopic dermatitis study 21 (non-lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):1.2927542
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (non-lesional; whole skin)
Non-lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

stem cell differentiation study 41 (T3pi) / stem cell differentiation study 41 (hES-T3 EB)

Relative Expression (log2-ratio):1.2837906
Number of Samples:2 / 2
Experimental stem cell differentiation study 41 (T3pi)
Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype.
Control stem cell differentiation study 41 (hES-T3 EB)
Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype.

Xq12?q13.3 duplication syndrome study 1 / normal lymphoblastoid cell line sample

Relative Expression (log2-ratio):-1.263773
Number of Samples:2 / 13
Experimental Xq12?q13.3 duplication syndrome study 1
Lymphoblastoid cell line samples from two brothers with Xq12?q13.3 duplication. The patients are affected by severe autism and global developmental delay with multiorgan involvement.
Control normal lymphoblastoid cell line sample
Lymphoblastoid cell line samples from healthy subjects.