TOP TEN perturbations for Q6PJQ5 (Homo sapiens)

Organism: Homo sapiens
Gene: Q6PJQ5
Selected probe(set): 1569669_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q6PJQ5 (1569669_at) across 5654 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):4.007138
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

NCI-H358 / HCC827

Relative Expression (log2-ratio):3.9449687
Number of Samples:6 / 6
Experimental NCI-H358
Human bronchioloalveolar carcinoma derived cell line. Synonyms:H358; H-358 Cellosaurus code:
Control HCC827
Human primary cancer cell line derived from the lung of a patient with non-small-cell lung cancer. Synonyms:HCC-827; HCC0827 Cellosaurus code:

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):3.173098
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

HCC study 6 (primary; adrenal gland metastasis) / HCC study 6 (primary; no metastasis)

Relative Expression (log2-ratio):1.3473806
Number of Samples:2 / 10
Experimental HCC study 6 (primary; adrenal gland metastasis)
Liver tissue sample from the primary site of patients with hepatocellular carcinoma (HCC) that metastasized to adrenal gland.
Control HCC study 6 (primary; no metastasis)
Liver tissue sample from the primary site of patients with hepatocellular carcinoma (HCC). Tumor did not metastasize.

DLBCL study 1 (germinal center B-cell like; plasmablast-like) / DLBCL study 1 (activated B-cell like; plasmablast-like)

Relative Expression (log2-ratio):1.3076262
Number of Samples:3 / 12
Experimental DLBCL study 1 (germinal center B-cell like; plasmablast-like)
Plasmablast B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (germinal center B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).
Control DLBCL study 1 (activated B-cell like; plasmablast-like)
Plasmablast B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (activated B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).

DLBCL study 7 (GCB; plasmablast-like) / DLBCL study 7 (GCB; centrocyte-like)

Relative Expression (log2-ratio):1.2742143
Number of Samples:3 / 15
Experimental DLBCL study 7 (GCB; plasmablast-like)
Primary tumor samples from patients with diffuse large B-cell lymphoma (germinal center B-cell like type). Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to plasmablast-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.
Control DLBCL study 7 (GCB; centrocyte-like)
Primary tumor samples from patients with diffuse large B-cell lymphoma (germinal center B-cell like type). Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to centrocyte-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.

DLBCL study 1 (germinal center B-cell like; plasmablast-like) / DLBCL study 1 (germinal center B-cell like; centroblast-like)

Relative Expression (log2-ratio):1.2302794
Number of Samples:3 / 14
Experimental DLBCL study 1 (germinal center B-cell like; plasmablast-like)
Plasmablast B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (germinal center B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).
Control DLBCL study 1 (germinal center B-cell like; centroblast-like)
Centroblast B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (germinal center B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).

DLBCL study 1 (germinal center B-cell like; plasmablast-like) / DLBCL study 1 (germinal center B-cell like; centrocyte-like)

Relative Expression (log2-ratio):1.1686802
Number of Samples:3 / 25
Experimental DLBCL study 1 (germinal center B-cell like; plasmablast-like)
Plasmablast B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (germinal center B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).
Control DLBCL study 1 (germinal center B-cell like; centrocyte-like)
Centrocyte B-cells sorted from primary tumor samples from patients with malignant diffuse large B-cell lymphoma (germinal center B-cell like type). To isolate different B-cell subsets, tonsil tissues from DLBCL patients were sorted by fluorescence-activated cell sorting. Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS).

systemic lupus erythematosus study 13 (untreated) / normal PBMC sample

Relative Expression (log2-ratio):-1.0905137
Number of Samples:4 / 5
Experimental systemic lupus erythematosus study 13 (untreated)
Peripheral blood mononuclear cells (PBMCs) obtained from systemic lupus erythematosus (SLE) patients. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours. Lupus patients fulfilled American College of Rheumatology classification criteria for disease, and disease activity was quantified by SLEDAI. Patients were excluded if they showed symptoms of recent or active infection or were pregnant. None of the patients was taking Pioglitazone or other PPAR-γ agonists.
Control normal PBMC sample
Peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours.

male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-0.966393
Number of Samples:2 / 8
Experimental male infertility study 1 (juvenile; Ad-)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).