TOP TEN perturbations for Q86UP8 (Homo sapiens)

Organism: Homo sapiens
Gene: Q86UP8
Selected probe(set): 228765_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q86UP8 (228765_at) across 5392 perturbations tested by GENEVESTIGATOR:

Barrett's esophagus study 3 / esophageal squamous cell carcinoma study 1

Relative Expression (log2-ratio):-2.100689
Number of Samples:17 / 8
Experimental Barrett's esophagus study 3
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control esophageal squamous cell carcinoma study 1
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.

oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample

Relative Expression (log2-ratio):-1.9591761
Number of Samples:3 / 3
Experimental oncolytic herpes simplex virus study 2
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control mock infected peripheral nerve sheath tumor (S462) cell sample
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.

esophageal squamous cell carcinoma study 1 / normal esophageal epithelium sample

Relative Expression (log2-ratio):1.8935137
Number of Samples:8 / 18
Experimental esophageal squamous cell carcinoma study 1
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.
Control normal esophageal epithelium sample
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

sodium chromate; SOV study 1 / untreated LL24 cell sample

Relative Expression (log2-ratio):-1.7290335
Number of Samples:4 / 4
Experimental sodium chromate; SOV study 1
Human lung fibroblast cell line (LL24) treated for 24 hours with 1 uM sodium chromate (Na2CrO4.4H2O; [Cr(VI)]) in the presence of 10 uM sodium orthovanadate (SOV). SOV was added 30 minutes prior to Cr(VI). For the experiment 2x106 cells/150 mm dish were seeded. ATC code:---
Control untreated LL24 cell sample
Untreated human lung fibroblast cell line (LL24). For the experiment 2x106 cells/150 mm dish were seeded and RNA extracted after 24h.

glioma study 16 (BS-149) / normal astrocyte sample

Relative Expression (log2-ratio):1.728569
Number of Samples:2 / 3
Experimental glioma study 16 (BS-149)
Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37?C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

IL-4; GM-CSF study 1 (intermediate) / untreated monocyte sample

Relative Expression (log2-ratio):-1.6889391
Number of Samples:7 / 12
Experimental IL-4; GM-CSF study 1 (intermediate)
Monocytes, cultured with vehicle (DMSO/ethanol) and 500 U/ml IL-4 and 800 U/ml GM-CSF for 24 hours.
Control untreated monocyte sample
Freshly isolated human monocytes from healthy donors.

esophageal squamous cell carcinoma study 1 / esophageal adenocarcinoma study 1

Relative Expression (log2-ratio):1.6614981
Number of Samples:8 / 20
Experimental esophageal squamous cell carcinoma study 1
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.
Control esophageal adenocarcinoma study 1
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.

valproic acid study 26 (2000uM) / vehicle (PBS) treated HepG2 sample

Relative Expression (log2-ratio):-1.6430178
Number of Samples:3 / 12
Experimental valproic acid study 26 (2000uM)
HepG2 cells treated with compound: valproic acid (2000uM; CAS no.:99-66-1) for 24 hours. Valproic acid is hepatotoxic and may cause steatosis. HepG2 cells were treated with the IC20 concentration measured after 24 hours. ATC code:
Control vehicle (PBS) treated HepG2 sample
HepG2 cells treated with PBS (0.5% v/v) as solvent control for 24 hours.

Alzheimer's disease study 6 / normal large stellate neuron (entorhinal cortex)

Relative Expression (log2-ratio):-1.5936441
Number of Samples:10 / 12
Experimental Alzheimer's disease study 6
Large stellate neurons of the entorhinal cortex, collected from layer II of clinically and neuropathologically classified late-onset Alzheimer?s disease afflicted individuals. Subjects in this group had a Braak stage of V or VI with a CERAD score of moderate or frequent.
Control normal large stellate neuron (entorhinal cortex)
Large stellate neurons of the entorhinal cortex, collected from layer II of clinically classified as neurologically normal individuals. Subjects in this group had a Braak stage ranging from I to II with a infrequent Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuritic plaque density.

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue

Relative Expression (log2-ratio):1.5838318
Number of Samples:4 / 3
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue
Normal adult kidney tissue samples.