TOP TEN perturbations for Q8N135 (Homo sapiens)

Organism: Homo sapiens
Gene: Q8N135
Selected probe(set): 227821_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q8N135 (227821_at) across 5880 perturbations tested by GENEVESTIGATOR:

connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; primary)

Relative Expression (log2-ratio):2.6859303
Number of Samples:3 / 7
Experimental connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.
Control connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted).

renal cell carcinoma study 1 (prim. tumor) / adjacent kidney tissue

Relative Expression (log2-ratio):1.9392948
Number of Samples:3 / 3
Experimental renal cell carcinoma study 1 (prim. tumor)
Tumor tissue from the primary tumor of patients with renal cell carcinoma (RCC).
Control adjacent kidney tissue
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

renal cell carcinoma study 1 (metastasis) / adjacent kidney tissue

Relative Expression (log2-ratio):1.896184
Number of Samples:3 / 3
Experimental renal cell carcinoma study 1 (metastasis)
Tumor tissue from metastases of patients with renal cell carcinoma (RCC).
Control adjacent kidney tissue
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

atypical teratoid/rhabdoid tumor study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):-1.8248129
Number of Samples:20 / 9
Experimental atypical teratoid/rhabdoid tumor study 1
Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

brain tumor study 1 (medulloblastoma) / normal brain tissue

Relative Expression (log2-ratio):-1.8175478
Number of Samples:22 / 12
Experimental brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

medulloblastoma study 2 / non-tumor brain tissue

Relative Expression (log2-ratio):-1.7972469
Number of Samples:4 / 9
Experimental medulloblastoma study 2
Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

adrenal gland cancer study 4 / normal adrenal cortex tissue

Relative Expression (log2-ratio):-1.737606
Number of Samples:43 / 4
Experimental adrenal gland cancer study 4
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples derived after autopsy.

medulloblastoma study 1 / non-tumor brain tissue

Relative Expression (log2-ratio):-1.5556583
Number of Samples:17 / 9
Experimental medulloblastoma study 1
Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.
Control non-tumor brain tissue
Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

clear cell renal cell carcinoma study 4 (stage 4) / normal kidney tissue

Relative Expression (log2-ratio):1.5388489
Number of Samples:14 / 69
Experimental clear cell renal cell carcinoma study 4 (stage 4)
Primary tumor tissue from patients with stage 4 clear cell renal cell carcinoma (ccRCC).
Control normal kidney tissue
Normal kidney tissue samples obtained from healthy individuals.

endometriosis study 5 (endo. lesion; proliferative MCP) / endometriosis study 5 (eutopic endometrium; proliferative MCP)

Relative Expression (log2-ratio):1.4737053
Number of Samples:8 / 8
Experimental endometriosis study 5 (endo. lesion; proliferative MCP)
Peritoneal endometriosis lesion samples collected from women with endometriosis in the proliferative menstrual cycle phase (MCP). The endometrial samples were obtained by laparoscopy or laparotomy. Women had complete MCPs including those patients where hormone therapy was stopped at 3 to 6 months before surgery. The MCP was determined according to a combination of measurement of hormone serum levels, gene expression of a cycle-phase specific genes, and the knowledge of the patient’s last menstrual cycle.
Control endometriosis study 5 (eutopic endometrium; proliferative MCP)
Eutopic endometrial tissue samples collected from women with endometriosis in the proliferative menstrual cycle phase (MCP). The endometrial samples were obtained by laparoscopy or laparotomy. Women had complete MCPs including those patients where hormone therapy was stopped at 3 to 6 months before surgery. The MCP was determined according to a combination of measurement of hormone serum levels, gene expression of a cycle-phase specific genes, the knowledge of the patient’s last menstrual cycle, and analysis of specific histological criteria to identify menstrual cycle phases.