TOP TEN perturbations for Q8N5U1 (Homo sapiens)

Organism: Homo sapiens
Gene: Q8N5U1
Selected probe(set): 1564194_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q8N5U1 (1564194_a_at) across 5880 perturbations tested by GENEVESTIGATOR:

lung cancer study 1 (PDX; squamous cell carcinoma, NOS; primary) / lung cancer study 1 (PDX; adenosquamous carcinoma; primary)

Relative Expression (log2-ratio):-2.651147
Number of Samples:43 / 4
Experimental lung cancer study 1 (PDX; squamous cell carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary squamous cell carcinoma, NOS of the lung (subcutaneously implanted).
Control lung cancer study 1 (PDX; adenosquamous carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenosquamous carcinoma of the lung (subcutaneously implanted).

lung squamous cell carcinoma study 1 / normal lung tissue

Relative Expression (log2-ratio):-2.6400347
Number of Samples:31 / 44
Experimental lung squamous cell carcinoma study 1
Primary lung squamous cell carcinoma samples of a patient with non-small cell lung cancer.
Control normal lung tissue
Histologically normal lung tissue.

lung cancer study 1 (PDX; adenosquamous carcinoma; primary) / lung cancer study 1 (PDX; adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):2.5311852
Number of Samples:4 / 22
Experimental lung cancer study 1 (PDX; adenosquamous carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenosquamous carcinoma of the lung (subcutaneously implanted).
Control lung cancer study 1 (PDX; adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenocarcinoma, NOS of the lung (subcutaneously implanted).

lung adenocarcinoma study 4 / normal lung tissue

Relative Expression (log2-ratio):-2.3189697
Number of Samples:14 / 44
Experimental lung adenocarcinoma study 4
Primary lung adenocarcinoma samples of a patient with non-small cell lung cancer.
Control normal lung tissue
Histologically normal lung tissue.

lung adenocarcinoma study 3 / adjacent lung tissue

Relative Expression (log2-ratio):-2.2225351
Number of Samples:93 / 98
Experimental lung adenocarcinoma study 3
Primary adenocarcinoma samples from the lung of patients with different stages and smoking status.
Control adjacent lung tissue
Adjacent, histologically normal and non-neoplastic tissue sample from the lung of patients with primary adenocarcinoma of the lung. Patients had different stages and smoking status.

non-small cell lung cancer study 2 / adjacent lung tissue

Relative Expression (log2-ratio):-2.077114
Number of Samples:60 / 60
Experimental non-small cell lung cancer study 2
Primary non-small cell lung cancer sample of female Asian non-smoker.
Control adjacent lung tissue
Adjacent normal part of non-small cell lung cancer samples of female Asian non-smoker.

non-small cell lung cancer study 8 (squamous cell carcinoma) / adjacent lung tissue

Relative Expression (log2-ratio):-1.6159172
Number of Samples:27 / 65
Experimental non-small cell lung cancer study 8 (squamous cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients squamous cell carcinoma.
Control adjacent lung tissue
Histological normal lung tissue samples from patients with lung cancer.

non-small cell lung cancer study 8 (adenocarcinoma) / adjacent lung tissue

Relative Expression (log2-ratio):-1.3237724
Number of Samples:45 / 65
Experimental non-small cell lung cancer study 8 (adenocarcinoma)
Primary tumor tissue sample obtained from the lung of patients adenocarcinoma.
Control adjacent lung tissue
Histological normal lung tissue samples from patients with lung cancer.

smoking study 13 (current smoker) / adenocarcinoma lung tissue (never smoker)

Relative Expression (log2-ratio):-1.3038254
Number of Samples:16 / 8
Experimental smoking study 13 (current smoker)
Lung tumor samples of current smokers diagnosed with lung adenocarcinoma.
Control adenocarcinoma lung tissue (never smoker)
Lung samples of never smokers diagnosed with lung adenocarcinoma.

lung adenocarcinoma study 3 (negative) / normal lung tissue

Relative Expression (log2-ratio):-1.2931328
Number of Samples:9 / 3
Experimental lung adenocarcinoma study 3 (negative)
Primary lung adenocarcinoma samples, with bone marrow negative for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.