TOP TEN perturbations for Q8NGT1 (Homo sapiens)

Organism: Homo sapiens
Gene: Q8NGT1
Selected probe(set): 1567273_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q8NGT1 (1567273_at) across 5610 perturbations tested by GENEVESTIGATOR:

glioma study 17 (astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):-0.73757696
Number of Samples:3 / 3
Experimental glioma study 17 (astrocytoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from low grade astrocytoma (grade II). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 36 ? 7 years old.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

brefeldin A study 1 (0.5ug/ml; HCT 116) / untreated HCT 116 cell sample

Relative Expression (log2-ratio):-0.6986408
Number of Samples:3 / 3
Experimental brefeldin A study 1 (0.5ug/ml; HCT 116)
Human colon carcinoma cell line HCT116 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:---
Control untreated HCT 116 cell sample
Human colon carcinoma cell line HCT116 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS.

necrotizing myopathy study 2 / inclusion body myositis study 2

Relative Expression (log2-ratio):0.66047955
Number of Samples:2 / 5
Experimental necrotizing myopathy study 2
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM).
Control inclusion body myositis study 2
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM).

F. tularensis study 1 (tularensis Schu S4) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):0.6132145
Number of Samples:4 / 6
Experimental F. tularensis study 1 (tularensis Schu S4)
Peripheral blood monocytes infected with the Schu S4 isolate of Francisella tularensis (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

retina pigment epithelium study 1 (adult) / retina pigment epithelium study 1 (fetal)

Relative Expression (log2-ratio):0.59807587
Number of Samples:2 / 6
Experimental retina pigment epithelium study 1 (adult)
Postmortem human native retina pigment epithelium samples from adult individuals.
Control retina pigment epithelium study 1 (fetal)
Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18.

smoking study 83 (smoker) / smoking study 83 (non-smoker)

Relative Expression (log2-ratio):0.57799244
Number of Samples:2 / 2
Experimental smoking study 83 (smoker)
Air-liquid interface lung epithelial culture exposed to cigarette smoke (30 mins exposure on four separate days). Lung epithelial cells were isolated from smokers and cultures were placed in smoking chambers with basal surface in contact with media. They were continually exposed to smoke (from filtered Kentucky reference (3R4F) cigarettes) for 30mins on days 1, 2, 5 and 6 (smoke/air dilution of 1:10 or 1:20).
Control smoking study 83 (non-smoker)
Air-liquid interface lung epithelial culture exposed to cigarette smoke (30 mins exposure on four separate days). Lung epithelial cells were isolated from non-smokers and cultures were placed in smoking chambers with basal surface in contact with media. They were continually exposed to smoke (from filtered Kentucky reference (3R4F) cigarettes) for 30mins on days 1, 2, 5 and 6 (smoke/air dilution of 1:10 or 1:20).

N-acetylcysteine study 1 / vehicle (DMSO) treated Hs 294T cell sample

Relative Expression (log2-ratio):-0.55228996
Number of Samples:2 / 2
Experimental N-acetylcysteine study 1
Hs 294T cells (passage 11) treated with 5 mM N-acetylcysteine (INN: acetylcysteine) at timepoint 6 hours. ATC code:, ,
Control vehicle (DMSO) treated Hs 294T cell sample
Hs 294T cells (passage 11) treated with 0.01% DMSO at timepoint 6 hours.

smoking study 82 (pMRTP; 33puffs/l; 24h) / smoking study 82 (pMRTP; 33puffs/l; 4h)

Relative Expression (log2-ratio):-0.54398775
Number of Samples:3 / 3
Experimental smoking study 82 (pMRTP; 33puffs/l; 24h)
Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of aerosol from a prototypic modified risk tobacco product (pMRTP; high concentration=33 puffs/l) for 24 hours. AE was generated by bubbling mainstream aerosol from pMRTP through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). pMRTP test sticks were provided by Philip Morris Products. Aerosol of pMRTP was generated by heating (rather than burning) tobacco using a fast-lighting carbon tip.
Control smoking study 82 (pMRTP; 33puffs/l; 4h)
Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of aerosol from a prototypic modified risk tobacco product (pMRTP; high concentration=33 puffs/l) for 4 hours. AE was generated by bubbling mainstream aerosol from pMRTP through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). pMRTP test sticks were provided by Philip Morris Products. Aerosol of pMRTP was generated by heating (rather than burning) tobacco using a fast-lighting carbon tip.

oxyphilic adenoma study 1 / normal kidney tissue

Relative Expression (log2-ratio):0.53827477
Number of Samples:4 / 2
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue
Normal fetal kidney tissue samples.

influenza virus study 10 (A/H5N2) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):-0.529006
Number of Samples:3 / 3
Experimental influenza virus study 10 (A/H5N2)
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F189/07/2004(H5N2). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.