TOP TEN perturbations for Q99706 (Homo sapiens)

Organism: Homo sapiens
Gene: Q99706
Selected probe(set): 208426_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q99706 (208426_x_at) across 5339 perturbations tested by GENEVESTIGATOR:

tetanus toxin study 1 / cytomegalovirus study 1

Relative Expression (log2-ratio):-2.8404512
Number of Samples:3 / 3
Experimental tetanus toxin study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with tetanus toxoid (tetanospasmin) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC?s.
Control cytomegalovirus study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with CMV-antigens (lysate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC?s.

cytomegalovirus study 1 / C. albicans study 1

Relative Expression (log2-ratio):2.7102327
Number of Samples:3 / 3
Experimental cytomegalovirus study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with CMV-antigens (lysate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC?s.
Control C. albicans study 1
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with Candida albicans-antigens (sonicate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC?s.

mycosis fungoides study 1 (tumor phase) / normal skin tissue

Relative Expression (log2-ratio):2.6037111
Number of Samples:4 / 8
Experimental mycosis fungoides study 1 (tumor phase)
Lesional skin biopsies from patients with mycosis fungoides in the plaque phase.
Control normal skin tissue
Skin biopsies from healthy individuals.

ovulation study 3 / proliferative phase endometrium tissue

Relative Expression (log2-ratio):2.0596647
Number of Samples:5 / 4
Experimental ovulation study 3
Late secretory phase (LSE) endometrium tissue.
Control proliferative phase endometrium tissue
Proliferative phase (PE) endometrium tissue.

kidney transplantation study 13 (12 week) / normal T-cell (CD8+) sample

Relative Expression (log2-ratio):2.040884
Number of Samples:6 / 5
Experimental kidney transplantation study 13 (12 week)
CD8+ T-cell samples derived from kidney transplant patients 12 weeks post-transplantation. Samples were collected 12 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal T-cell (CD8+) sample
CD8+ T-cell samples derived from healthy control subjects.

MALT lymphoma study 1 / normal spleen tissue

Relative Expression (log2-ratio):-1.5422945
Number of Samples:8 / 6
Experimental MALT lymphoma study 1
Human t(11;18)-negative mucosa-associated lymphoid tissue (MALT) lymphoma cells.
Control normal spleen tissue
Normal human spleen tissue sample.

ALL study 2 (15d) / ALL study 2 (0d)

Relative Expression (log2-ratio):1.4961987
Number of Samples:45 / 129
Experimental ALL study 2 (15d)
Bone marrow samples from children with de novo acute lymphoblastic leukemia. Samples were taken 15 days after remission-induction therapy (RIT).
Control ALL study 2 (0d)
Bone marrow samples from children with de novo acute lymphoblastic leukemia. Samples were taken before remission-induction therapy (RIT).

LPS study 4 (shRNA cycT1) / cycT1 depletion study 2 (shRNA)

Relative Expression (log2-ratio):1.4846916
Number of Samples:2 / 2
Experimental LPS study 4 (shRNA cycT1)
MONO-MAC-6 (MM6) cells were transduced with shRNA against cyclin T1 and then treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control cycT1 depletion study 2 (shRNA)
MONO-MAC-6 (MM6) cells were transduced with shRNA against cyclin T1 and then mock treated.

LPS study 4 (shRNA contr.) / mock treated / transduced MONO-MAC-6 cell sample

Relative Expression (log2-ratio):1.4813652
Number of Samples:2 / 2
Experimental LPS study 4 (shRNA contr.)
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control mock treated / transduced MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then mock treated.

MALT lymphoma study 2 / normal spleen tissue

Relative Expression (log2-ratio):-1.4422245
Number of Samples:6 / 6
Experimental MALT lymphoma study 2
Human t(11;18)-positive mucosa-associated lymphoid tissue (MALT) lymphoma cells.
Control normal spleen tissue
Normal human spleen tissue sample.