TOP TEN perturbations for Q9BUN8 (Homo sapiens)

Organism: Homo sapiens
Gene: Q9BUN8
Selected probe(set): 219402_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q9BUN8 (219402_s_at) across 5610 perturbations tested by GENEVESTIGATOR:

renal cell carcinoma study 1 (metastasis) / adjacent kidney tissue

Relative Expression (log2-ratio):2.586504
Number of Samples:3 / 3
Experimental renal cell carcinoma study 1 (metastasis)
Tumor tissue from metastases of patients with renal cell carcinoma (RCC).
Control adjacent kidney tissue
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

renal cell carcinoma study 1 (prim. tumor) / adjacent kidney tissue

Relative Expression (log2-ratio):2.3531218
Number of Samples:3 / 3
Experimental renal cell carcinoma study 1 (prim. tumor)
Tumor tissue from the primary tumor of patients with renal cell carcinoma (RCC).
Control adjacent kidney tissue
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):2.0709467
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

atopic dermatitis study 21 (lesional; epidermis) / normal epidermis tissue

Relative Expression (log2-ratio):2.0409698
Number of Samples:5 / 10
Experimental atopic dermatitis study 21 (lesional; epidermis)
Lesional epidermal samples isolated from patient with moderate-to-severe chronic atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal epidermis tissue
Epidermal samples isolated from healthy subjects by laser capture microdissection.

P. aeruginosa study 3 (∆F508-CFTR compl) / P. aeruginosa study 3 (wt-CFTR compl)

Relative Expression (log2-ratio):-1.9886303
Number of Samples:4 / 4
Experimental P. aeruginosa study 3 (∆F508-CFTR compl)
Human bronchial epithelial cell line homozygous for the cystic fibrosis mutation F508-CFTR and complemented with ∆F508-CFTR infected for 1 hour with P. aeruginosa stain PAO1 (MOI 30:1). Cells were seeded on Trans-well filters and grown in air-liquid interface for 8 days to develop polarized monolayers. P. aeruginosa was applied to the cells by removing the medium from the apical side and replacing it with equivalent volume of antibiotics-free medium containing bacteria. After 1h stimulation cells were washed twice in medium and mRNA isolated five hours later.
Control P. aeruginosa study 3 (wt-CFTR compl)
Human bronchial epithelial cell line homozygous for the cystic fibrosis mutation F508-CFTR and complemented with wt-CFTR infected for 1 hour with P. aeruginosa stain PAO1 (MOI 30:1). Cells were seeded on Trans-well filters and grown in air-liquid interface for 8 days to develop polarized monolayers. P. aeruginosa was applied to the cells by removing the medium from the apical side and replacing it with equivalent volume of antibiotics-free medium containing bacteria. After 1h stimulation cells were washed twice in medium and mRNA isolated five hours later.

atopic dermatitis study 21 (lesional; whole skin) / normal skin tissue

Relative Expression (log2-ratio):1.9665833
Number of Samples:5 / 6
Experimental atopic dermatitis study 21 (lesional; whole skin)
Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control normal skin tissue
Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

cystic fibrosis study 4 (∆F508-CFTR compl) / cystic fibrosis study 4 (wt-CFTR compl)

Relative Expression (log2-ratio):-1.9199896
Number of Samples:4 / 4
Experimental cystic fibrosis study 4 (∆F508-CFTR compl)
Uninfected human bronchial epithelial cell line homozygous for the cystic fibrosis mutation F508-CFTR (Cystic fibrosis transmembrane conductance regulator) and complemented with ∆F508-CFTR. Cells were seeded on Trans-well filters and grown in air-liquid interface for 8 days to develop polarized monolayers. Vehicle was applied to the cells by removing the medium from the apical side and replacing it with equivalent volume of antibiotics-free medium. After 1h vehicle treatment cells were washed twice in medium and mRNA isolated five hours later.
Control cystic fibrosis study 4 (wt-CFTR compl)
Uninfected human bronchial epithelial cell line homozygous for the cystic fibrosis mutation F508-CFTR (Cystic fibrosis transmembrane conductance regulator) and complemented with wt-CFTR. Cells were seeded on Trans-well filters and grown in air-liquid interface for 8 days to develop polarized monolayers. Vehicle was applied to the cells by removing the medium from the apical side and replacing it with equivalent volume of antibiotics-free medium. After 1h vehicle treatment cells were washed twice in medium and mRNA isolated five hours later.

Dengue hemorrhagic fever study 1 (5d) / Dengue hemorrhagic fever study 1 (convalescent)

Relative Expression (log2-ratio):1.9008379
Number of Samples:5 / 12
Experimental Dengue hemorrhagic fever study 1 (5d)
Peripheral blood mononuclear cell (PBMC) samples derived from the blood of Venezuelan individuals 5 days after the onset of Dengue hemorrhagic fever.
Control Dengue hemorrhagic fever study 1 (convalescent)
Peripheral blood mononuclear cell (PBMC) samples derived from the blood of Venezuelan individuals 28 days after the onset of Dengue hemorrhagic fever.

colorectal adenoma study 2 / normal colon tissue

Relative Expression (log2-ratio):-1.8047676
Number of Samples:5 / 6
Experimental colorectal adenoma study 2
Laser microdissected human adenoma sample.
Control normal colon tissue
Laser microdissected human colonic epithelial cells sample.

ovarian tumor study 17 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):1.7666245
Number of Samples:9 / 10
Experimental ovarian tumor study 17
Human epithelial tumor cell samples from the ovary of patients with primary clear cell carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases.