TOP TEN perturbations for Q9H8L6 (Homo sapiens)

Organism: Homo sapiens
Gene: Q9H8L6
Selected probe(set): 219091_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q9H8L6 (219091_s_at) across 5217 perturbations tested by GENEVESTIGATOR:

PMA study 6 (500ng/ml) / vehicle (DME) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):3.831479
Number of Samples:3 / 17
Experimental PMA study 6 (500ng/ml)
Bronchial epithelial cells (NHBE) treated with tetradecanoylphorbol acetate (500ng/ml; vendor: Sigma / catalog number: P1585 / catalog name: Phorbol 12-myristate 13-acetate [16561-29-8]) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:---
Control vehicle (DME) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

lung adenocarcinoma study 3 (positive) / normal lung tissue

Relative Expression (log2-ratio):-2.988737
Number of Samples:7 / 3
Experimental lung adenocarcinoma study 3 (positive)
Primary lung adenocarcinoma samples, with bone marrow positive for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.

breast cancer study 8 (primary) / normal breast tissue

Relative Expression (log2-ratio):-2.7467422
Number of Samples:13 / 4
Experimental breast cancer study 8 (primary)
Human primary infiltrating ductal carcinoma sample of a female patient with breast cancer.
Control normal breast tissue
Normal human breast samples of healthy female individuals.

breast cancer study 8 (metastatic) / normal breast tissue

Relative Expression (log2-ratio):-2.6442394
Number of Samples:2 / 4
Experimental breast cancer study 8 (metastatic)
Human metastatic infiltrating ductal carcinoma sample of the breast derived from lymph nodes of a female patient with breast cancer.
Control normal breast tissue
Normal human breast samples of healthy female individuals.

lung adenocarcinoma study 3 (negative) / normal lung tissue

Relative Expression (log2-ratio):-2.551034
Number of Samples:9 / 3
Experimental lung adenocarcinoma study 3 (negative)
Primary lung adenocarcinoma samples, with bone marrow negative for early disseminated tumor cells (DTCs). The presence of DTCs can predict the subsequent occurrence of overt metastasis and survival in lung cancer.
Control normal lung tissue
Normal lung tissue.

non-small cell lung cancer study 8 (large cell carcinoma) / adjacent lung tissue

Relative Expression (log2-ratio):-2.4152966
Number of Samples:18 / 65
Experimental non-small cell lung cancer study 8 (large cell carcinoma)
Primary tumor tissue sample obtained from the lung of patients large cell carcinoma.
Control adjacent lung tissue
Histological normal lung tissue samples from patients with lung cancer.

lung adenocarcinoma study 6 (K-RAS mut) / adjacent lung tissue

Relative Expression (log2-ratio):-2.3649359
Number of Samples:6 / 20
Experimental lung adenocarcinoma study 6 (K-RAS mut)
Primary tumor sample from patients with stage II adenocarcinoma carrying a K-RAS mutation.
Control adjacent lung tissue
Adjacent and histologically normal, non-tumorous lung tissue samples from patients with lung adenocarcinoma.

renal cell carcinoma study 5 (papillary type) / normal kidney tissue

Relative Expression (log2-ratio):-2.313364
Number of Samples:19 / 3
Experimental renal cell carcinoma study 5 (papillary type)
Tumor tissue samples from the kidney of patients with papillary renal cell carcinoma (pRCC).
Control normal kidney tissue
Normal adult kidney tissue samples.

lung adenocarcinoma study 3 / adjacent lung tissue

Relative Expression (log2-ratio):-2.27637
Number of Samples:93 / 98
Experimental lung adenocarcinoma study 3
Primary adenocarcinoma samples from the lung of patients with different stages and smoking status.
Control adjacent lung tissue
Adjacent, histologically normal and non-neoplastic tissue sample from the lung of patients with primary adenocarcinoma of the lung. Patients had different stages and smoking status.

breast cancer study 16 (inv. dc) / adjacent breast tissue

Relative Expression (log2-ratio):-2.2628717
Number of Samples:22 / 27
Experimental breast cancer study 16 (inv. dc)
Primary invasive ductal carcinoma tissue sample derived from the breasts of female patients after surgery.
Control adjacent breast tissue
Histologically normal breast tissue samples obtained from a clinically unaffected site from patients with primary invasive breast cancer.