TOP TEN perturbations for Q9NZH6 (Homo sapiens)

Organism: Homo sapiens
Gene: Q9NZH6
Selected probe(set): 224555_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q9NZH6 (224555_x_at) across 5392 perturbations tested by GENEVESTIGATOR:

skin transplantation study 1 (3d) / normal skin tissue (skin grafting)

Relative Expression (log2-ratio):-4.6536083
Number of Samples:6 / 8
Experimental skin transplantation study 1 (3d)
Human skin punch biopsy from patients after skin grafting. Sample was taken at the site of re-epithelialization 3 days after surgery.
Control normal skin tissue (skin grafting)
Skin biopsy samples from healthy control subjects after breast or abdomen reduction surgery.

split-thickness skin grafting study 1 / normal skin tissue (skin grafting)

Relative Expression (log2-ratio):-4.518647
Number of Samples:6 / 8
Experimental split-thickness skin grafting study 1
Skin punch biopsy from patients with skin injury (burn injury, congelation, wound, compartment syndrome) immediately after split-thickness skin grafting was done. Sample was taken from the acute wound after grafting.
Control normal skin tissue (skin grafting)
Skin biopsy samples from healthy control subjects after breast or abdomen reduction surgery.

skin transplantation study 1 (7d) / normal skin tissue (skin grafting)

Relative Expression (log2-ratio):-4.3372164
Number of Samples:5 / 8
Experimental skin transplantation study 1 (7d)
Human skin punch biopsy from patients after skin grafting. Sample was taken at the site of re-epithelialization 7 days after surgery.
Control normal skin tissue (skin grafting)
Skin biopsy samples from healthy control subjects after breast or abdomen reduction surgery.

wound healing study 2 (ex vivo; DMSO) / normal skin tissue (ex vivo)

Relative Expression (log2-ratio):-4.2436724
Number of Samples:3 / 3
Experimental wound healing study 2 (ex vivo; DMSO)
Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing DMSO for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 1:1000 fold dilution of DMSO. The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin.
Control normal skin tissue (ex vivo)
Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

Merkel cell carcinoma study 3 (metastatic) / normal skin tissue

Relative Expression (log2-ratio):-3.903514
Number of Samples:22 / 64
Experimental Merkel cell carcinoma study 3 (metastatic)
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control normal skin tissue
Normal skin samples from healthy donors.

Merkel cell carcinoma study 3 (primary) / normal skin tissue

Relative Expression (log2-ratio):-3.8079443
Number of Samples:38 / 64
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control normal skin tissue
Normal skin samples from healthy donors.

split-thickness skin grafting study 2 (NPWT) / normal skin tissue (skin grafting)

Relative Expression (log2-ratio):-3.7066965
Number of Samples:4 / 6
Experimental split-thickness skin grafting study 2 (NPWT)
Skin punch biopsy from patients that underwent split-thickness skin grafting. Sample was taken from the wound site 7 days after grafting. Patients received negative-pressure wound therapy (NPWT) immediately after grafting .
Control normal skin tissue (skin grafting)
Skin punch biopsy samples from healthy patients before slit-thickness skin grafting.

skin squamous cell carcinoma study 6 / normal skin tissue

Relative Expression (log2-ratio):-3.6528406
Number of Samples:4 / 64
Experimental skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).
Control normal skin tissue
Normal skin samples from healthy donors.

basal cell carcinoma study 2 / normal skin tissue

Relative Expression (log2-ratio):-3.525732
Number of Samples:2 / 64
Experimental basal cell carcinoma study 2
Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC).
Control normal skin tissue
Normal skin samples from healthy donors.

atopic dermatitis study 8 / normal skin tissue

Relative Expression (log2-ratio):-3.272976
Number of Samples:9 / 9
Experimental atopic dermatitis study 8
Lesional skin tissue samples from patients with acute exacerbation of chronic atopic dermatitis. All patients had elevated IgE levels, score of atopic dermatitis between 20-70 and were free of therapy > 4 weeks prior sample collection.
Control normal skin tissue
Skin biopsies from healthy individuals.