TOP TEN perturbations for Q9UBF1 (Homo sapiens)

Organism: Homo sapiens
Gene: Q9UBF1
Selected probe(set): 220062_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q9UBF1 (220062_s_at) across 5610 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):8.5375595
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):6.0523453
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

male infertility study 1 (mJS5) / male infertility study 1 (mJS2)

Relative Expression (log2-ratio):3.6373043
Number of Samples:8 / 7
Experimental male infertility study 1 (mJS5)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained spermatocytes but no spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS5.
Control male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.

male infertility study 1 (mJS7) / male infertility study 1 (mJS2)

Relative Expression (log2-ratio):2.823944
Number of Samples:4 / 7
Experimental male infertility study 1 (mJS7)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained early but no late spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS7.
Control male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.

HCC study 9 (HBV; HCV) / normal liver tissue

Relative Expression (log2-ratio):2.8090134
Number of Samples:2 / 10
Experimental HCC study 9 (HBV; HCV)
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control normal liver tissue
Normal, non-tumor liver tissue.

male infertility study 1 (mJS8) / male infertility study 1 (mJS2)

Relative Expression (log2-ratio):2.798112
Number of Samples:7 / 7
Experimental male infertility study 1 (mJS8)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained many early and elongated but only few mature spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS8.
Control male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.

HCC study 4 (area A) / non-tumor hepatocyte sample

Relative Expression (log2-ratio):2.7670822
Number of Samples:10 / 10
Experimental HCC study 4 (area A)
Microdissected hepatocyte samples from liver tissue biopsies taken from patients with HBV-associated HCC (hepatocellular carcinoma) after orthotopic liver transplantation (OLT) or partial hepatectomy. Tumorous, malignant sample was taken from the center of the tumor (area A). Patients were positive for hepatitis B surface antigen, antibody to hepatitis B core antigen and antibody to hepatitis B antigen and received antiviral treatment with nucleos(t)ide analogues prior to surgery.
Control non-tumor hepatocyte sample
Histologically normal, healthy microdissected hepatocyte samples from liver tissue biopsies obtained from a clinically unaffected site from patients with HBV-associated HCC (hepatocellular carcinoma) after orthotopic liver transplantation (OLT) or partial hepatectomy. Non-tumorous, non-malignant sample was taken from the unaffected edge of the liver (area E). Patients were positive for hepatitis B surface antigen, antibody to hepatitis B core antigen and antibody to hepatitis B antigen and received antiviral treatment with nucleos(t)ide analogues prior to surgery.

male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-2.6903133
Number of Samples:2 / 8
Experimental male infertility study 1 (juvenile; Ad-)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

oncolytic herpes simplex virus study 4 / mock infected peripheral nerve sheath tumor (26T) cell sample

Relative Expression (log2-ratio):-2.676055
Number of Samples:2 / 2
Experimental oncolytic herpes simplex virus study 4
Human malignant peripheral nerve sheath tumor (26T) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control mock infected peripheral nerve sheath tumor (26T) cell sample
Human malignant peripheral nerve sheath tumor (26T) cells mock infected for 6 hours.

male infertility study 1 (mJS2) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-2.602109
Number of Samples:7 / 8
Experimental male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).