TOP TEN perturbations for Q9ULZ0 (Homo sapiens)

Organism: Homo sapiens
Gene: Q9ULZ0
Selected probe(set): 220167_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q9ULZ0 (220167_s_at) across 5610 perturbations tested by GENEVESTIGATOR:

male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-5.124503
Number of Samples:2 / 8
Experimental male infertility study 1 (juvenile; Ad-)
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

systemic lupus erythematosus study 13 (untreated) / normal PBMC sample

Relative Expression (log2-ratio):-4.676387
Number of Samples:4 / 5
Experimental systemic lupus erythematosus study 13 (untreated)
Peripheral blood mononuclear cells (PBMCs) obtained from systemic lupus erythematosus (SLE) patients. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours. Lupus patients fulfilled American College of Rheumatology classification criteria for disease, and disease activity was quantified by SLEDAI. Patients were excluded if they showed symptoms of recent or active infection or were pregnant. None of the patients was taking Pioglitazone or other PPAR-γ agonists.
Control normal PBMC sample
Peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects. Freshly isolated PBMCs were cultured in RPMI/10% FBS for 6 hours.

male infertility study 1 (mJS2) / normal testicular lobules tissue (mJS10)

Relative Expression (log2-ratio):-3.7011929
Number of Samples:7 / 8
Experimental male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.
Control normal testicular lobules tissue (mJS10)
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10).

male infertility study 1 (mJS7) / male infertility study 1 (mJS2)

Relative Expression (log2-ratio):3.5392733
Number of Samples:4 / 7
Experimental male infertility study 1 (mJS7)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained early but no late spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS7.
Control male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.

male infertility study 1 (mJS8) / male infertility study 1 (mJS2)

Relative Expression (log2-ratio):3.4708414
Number of Samples:7 / 7
Experimental male infertility study 1 (mJS8)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained many early and elongated but only few mature spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS8.
Control male infertility study 1 (mJS2)
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2.

brodalumab study 2 (early) / untreated skin tissue (psoriasis)

Relative Expression (log2-ratio):-3.3714066
Number of Samples:4 / 2
Experimental brodalumab study 2 (early)
Lesional skin punch biopsies derived from patients with psoriasis. The punch biopsy was obtained from active, lesional skin after treatment with 350mg brodalumab for 8 days. ATC code:---
Control untreated skin tissue (psoriasis)
Untreated lesional skin biopsy samples from patients with psoriasis.

brodalumab study 1 (intermediate) / untreated skin tissue (psoriasis)

Relative Expression (log2-ratio):-3.2172604
Number of Samples:4 / 2
Experimental brodalumab study 1 (intermediate)
Lesional skin punch biopsies derived from patients with psoriasis. The punch biopsy was obtained from active, lesional skin after treatment with 140mg brodalumab for 15 days. ATC code:---
Control untreated skin tissue (psoriasis)
Untreated lesional skin biopsy samples from patients with psoriasis.

brodalumab study 1 (late) / untreated skin tissue (psoriasis)

Relative Expression (log2-ratio):-3.0066833
Number of Samples:4 / 2
Experimental brodalumab study 1 (late)
Lesional skin punch biopsies derived from patients with psoriasis. The punch biopsy was obtained from active, lesional skin after treatment with 140mg brodalumab for 43 days. ATC code:---
Control untreated skin tissue (psoriasis)
Untreated lesional skin biopsy samples from patients with psoriasis.

basal cell carcinoma study 2 / normal skin tissue

Relative Expression (log2-ratio):2.9736223
Number of Samples:2 / 64
Experimental basal cell carcinoma study 2
Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC).
Control normal skin tissue
Normal skin samples from healthy donors.

skin squamous cell carcinoma study 6 / normal skin tissue

Relative Expression (log2-ratio):2.9344664
Number of Samples:4 / 64
Experimental skin squamous cell carcinoma study 6
Primary tumor tissue from the skin of patients with squamous cell carcinoma (SCC).
Control normal skin tissue
Normal skin samples from healthy donors.