TOP TEN perturbations for Q9Y303 (Homo sapiens)

Organism: Homo sapiens
Gene: Q9Y303
Selected probe(set): 227841_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of Q9Y303 (227841_at) across 5880 perturbations tested by GENEVESTIGATOR:

IgG; C3bi stimulation study 1 (early) / normal polymorphnuclear leukocyte sample

Relative Expression (log2-ratio):2.6743507
Number of Samples:11 / 10
Experimental IgG; C3bi stimulation study 1 (early)
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated with IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 3h. ATC code:---
Control normal polymorphnuclear leukocyte sample
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated without IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 3h.

IgG; C3bi stimulation study 2 (early) / untreated polymorphnuclear leukocyte sample (Job's syndrome)

Relative Expression (log2-ratio):2.4290142
Number of Samples:7 / 7
Experimental IgG; C3bi stimulation study 2 (early)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated with IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 3h. ATC code:---
Control untreated polymorphnuclear leukocyte sample (Job's syndrome)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated without IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 3h.

IgG; C3bi stimulation study 2 (late) / untreated polymorphnuclear leukocyte sample (Job's syndrome)

Relative Expression (log2-ratio):1.9057665
Number of Samples:7 / 6
Experimental IgG; C3bi stimulation study 2 (late)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated with IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 6h. ATC code:---
Control untreated polymorphnuclear leukocyte sample (Job's syndrome)
Polymorphonuclear leukocytes (PMNs) from Job's syndrome patients, incubated without IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 6h.

B-CLL study 11 (rolipram) / rolipram study 4 (normal T-cell; 20uM)

Relative Expression (log2-ratio):1.8575115
Number of Samples:4 / 4
Experimental B-CLL study 11 (rolipram)
Peripheral blood mononuclear cells (PBMCs) obtained from chronic lymphocytic leukemia (CLL) patients and in vitro treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. PBMCs’ samples contained 90% CD19+ CD5+ B lineage CLL cells (B-CLL). Inclusion criteria: untreated CLL patients or at least 1 month after chemotherapy. Exclusion criteria: patients with active infections or other serious medical conditions or with white blood cell (WBC) counts of 15,000/l. ATC code:---
Control rolipram study 4 (normal T-cell; 20uM)
MACS purified T-cells from healthy donor peripheral blood treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. ATC code:---

IgG; C3bi stimulation study 1 (late) / normal polymorphnuclear leukocyte sample

Relative Expression (log2-ratio):1.7743893
Number of Samples:10 / 11
Experimental IgG; C3bi stimulation study 1 (late)
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated with IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 6h. ATC code:---
Control normal polymorphnuclear leukocyte sample
Polymorphonuclear leukocytes (PMNs) from healthy donors, incubated without IgG- and C3bi-coated latex beads at 37°C in a CO2 incubator for 6h.

B-CLL study 11 (rolipram) / rolipram study 4 (normal B-cell; 20uM)

Relative Expression (log2-ratio):1.6072168
Number of Samples:4 / 4
Experimental B-CLL study 11 (rolipram)
Peripheral blood mononuclear cells (PBMCs) obtained from chronic lymphocytic leukemia (CLL) patients and in vitro treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. PBMCs’ samples contained 90% CD19+ CD5+ B lineage CLL cells (B-CLL). Inclusion criteria: untreated CLL patients or at least 1 month after chemotherapy. Exclusion criteria: patients with active infections or other serious medical conditions or with white blood cell (WBC) counts of 15,000/l. ATC code:---
Control rolipram study 4 (normal B-cell; 20uM)
MACS purified resting B-cells from healthy donor peripheral blood treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. ATC code:---

glioma study 16 (BS-149) / normal astrocyte sample

Relative Expression (log2-ratio):1.3822489
Number of Samples:2 / 3
Experimental glioma study 16 (BS-149)
Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

influenza virus study 11 (A/H5N3) / influenza virus study 4 (A/H1N1)

Relative Expression (log2-ratio):-1.3563929
Number of Samples:3 / 3
Experimental influenza virus study 11 (A/H5N3)
Human carcinoma cell line A549 infected with influenza A virus subtype influenza virus A/duck/Malaysia/F119/3/1997(H5N3). Samples were taken 10 hours post-infection.
Control influenza virus study 4 (A/H1N1)
Human carcinoma cell line A549 infected with influenza A virus subtype A/WSN/33 (H1N1). Samples were taken 10 hours post-infection.

kidney transplantation study 15 (8 week) / normal monocyte (CD14+) sample

Relative Expression (log2-ratio):1.312355
Number of Samples:2 / 5
Experimental kidney transplantation study 15 (8 week)
CD14+ monocyte samples derived from kidney transplant patients 8 weeks post-transplantation. Samples were collected 8 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control normal monocyte (CD14+) sample
CD14+ monocyte samples derived from healthy control subjects.

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):1.2797165
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.