TOP TEN perturbations for P21129 (Mus musculus)

Organism: Mus musculus
Gene: P21129
Selected probe(set): 1451227_a_at
Platform: Affymetrix Mouse Genome 430 2.0 Array

Expression of P21129 (1451227_a_at) across 2667 perturbations tested by GENEVESTIGATOR:

muscle denervation study 1 (MCK::cre; runx f/f) / normal tibialis muscle (MCK::cre; runx f/f)

Relative Expression (log2-ratio):2.691554
Number of Samples:3 / 2
Experimental muscle denervation study 1 (MCK::cre; runx f/f)
3- day denervated tibialis anterior muscles derived from MCK::cre; runx f/f mice.
Control normal tibialis muscle (MCK::cre; runx f/f)
Innervated tibialis anterior muscles derived from MCK::cre; runx f/f mice.

muscle denervation study 1 (Runx1f/f) / normal tibialis muscle (Runx1f/f)

Relative Expression (log2-ratio):2.4621735
Number of Samples:3 / 3
Experimental muscle denervation study 1 (Runx1f/f)
3- day denervated tibialis anterior muscles derived from runx f/f control mice.
Control normal tibialis muscle (Runx1f/f)
Innervated tibialis anterior muscles derived from runx f/f control mice.

neural stem cell study 2 (ICAM-1(CD54)+) / neural stem cell study 2 (ICAM-1(CD54)-)

Relative Expression (log2-ratio):2.118143
Number of Samples:3 / 3
Experimental neural stem cell study 2 (ICAM-1(CD54)+)
FACS purified CD54 (ICAM-1) positive horizontal basal neural stem cells. Cells were isolated from olfactory epithelium of CD1 mice at P21-24.
Control neural stem cell study 2 (ICAM-1(CD54)-)
FACS purified CD54 (ICAM-1) negative horizontal basal neural stem cells. Cells were isolated from olfactory epithelium of CD1 mice at P21-24.

oocyte maturation study 1 (MII) / oocyte maturation study 1 (GV)

Relative Expression (log2-ratio):-2.1032085
Number of Samples:3 / 3
Experimental oocyte maturation study 1 (MII)
Mature oocytes isolated at MII stage of their maturation. Oocytes were harvested from 22-24 days old wildtype hybrid females of B6SJLF1 genetic background.
Control oocyte maturation study 1 (GV)
Fully grown oocytes isolated at GV stage of their maturation. Oocytes were harvested from 22-24 days old wildtype hybrid females of B6SJLF1 genetic background.

PNS cell type study 1 (P6, SG) / PNS cell type study 1 (P0, SG)

Relative Expression (log2-ratio):1.8785362
Number of Samples:4 / 4
Experimental PNS cell type study 1 (P6, SG)
Neurons from cochlear spiral ganglion (SG) were isolated from postnatal day 6 (P6) mice using FACS based on EGFP fluorescence.
Control PNS cell type study 1 (P0, SG)
Neurons from cochlear spiral ganglion (SG) were isolated from postnatal day 0 (P0) mice using FACS based on EGFP fluorescence.

glucose study 1 (16mM; young) / fresh pancreatic islet (C57BL/6; young)

Relative Expression (log2-ratio):1.6443253
Number of Samples:2 / 2
Experimental glucose study 1 (16mM; young)
Pancreatic islets isolated from 5 weeks old C57BL/6 mice cultured for 2 days in RPMI media containing 16mM glucose. Islets were isolated by collagenase digestion and a Histopaque gradient and allowed to recover over night in RPMI media containing 11 mM glucose, 10% FCS and penicillin/streptomycin.
Control fresh pancreatic islet (C57BL/6; young)
Pancreatic islets freshly isolated from 5 weeks old (young) C57BL/6 mice. Islets were isolated by collagenase digestion and a Histopaque gradient.

Sjögren syndrome study 3 (12wk; initial leukocytes’ influx) / normal salivary gland tissue (12wk; C57BL/6)

Relative Expression (log2-ratio):1.6172085
Number of Samples:5 / 5
Experimental Sjögren syndrome study 3 (12wk; initial leukocytes’ influx)
Salivary gland tissue from 12-week-old C57BL/6.NOD-Aec1Aec2 (also known as B6.NOD-Idd5NOD Idd3NOD) male mice representing the initial influx of leukocytes into the salivary glands, mouse model of primary Sjögren syndrome (pSS). One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland without any salivary lymph nodes, was analyzed.
Control normal salivary gland tissue (12wk; C57BL/6)
Normal salivary gland tissue from 12-week-old C57BL/6 male mice. One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland without any salivary lymph nodes, was analyzed.

B-cell activation study 4 (anti-IgM; CpG) / control B-cell sample (MRL/+ AM14)

Relative Expression (log2-ratio):1.4645548
Number of Samples:3 / 3
Experimental B-cell activation study 4 (anti-IgM; CpG)
Splenic B-cells from MRL/+ AM14 mice stimulated with a combination of anti-IgM F(ab´)2 (15 ug/ml) and CpG phosphorothiolate ODN 1826 (1 ug/ml) for six hours. Cells were isolated using magnetic beads (CD45R+/CD43-/CD4-/CD8-) and stimulated immediately after isolation.
Control control B-cell sample (MRL/+ AM14)
Splenic B-cells obtained from MRL/+ AM14 mice. Cells were isolated using magnetic beads (CD45R+/CD43-/CD4-/CD8-).

Sjögren syndrome study 3 (16wk; autoimmunity) / normal salivary gland tissue (16wk; C57BL/6)

Relative Expression (log2-ratio):1.4483299
Number of Samples:4 / 5
Experimental Sjögren syndrome study 3 (16wk; autoimmunity)
Salivary gland tissue from 16-week-old C57BL/6.NOD-Aec1Aec2 (also known as B6.NOD-Idd5NOD Idd3NOD) male mice representing the early clinical phase of autoimmunity, mouse model of primary Sjögren syndrome (pSS). One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland minus any salivary lymph nodes, was analyzed.
Control normal salivary gland tissue (16wk; C57BL/6)
Normal salivary gland tissue from 16-week-old C57BL/6 male mice. One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland without any salivary lymph nodes, was analyzed.

testis development study 7 (P20) / testis development study 7 (P3)

Relative Expression (log2-ratio):-1.3573437
Number of Samples:2 / 2
Experimental testis development study 7 (P20)
Testis tissue isolated from wildtype mice at postnatal day P20.
Control testis development study 7 (P3)
Testis tissue isolated from wildtype mice at postnatal day P3.