TOP TEN perturbations for Q811C2 (Mus musculus)

Organism: Mus musculus
Gene: Q811C2
Selected probe(set): 1434014_at
Platform: Affymetrix Mouse Genome 430 2.0 Array

Expression of Q811C2 (1434014_at) across 2667 perturbations tested by GENEVESTIGATOR:

lipopolysaccharide study 6 (LPS/mock) / lipopolysaccharide study 6 (mock, LPS)

Relative Expression (log2-ratio):2.8971138
Number of Samples:3 / 3
Experimental lipopolysaccharide study 6 (LPS/mock)
Macrophages were pretreated with 100 ng/ml lipopolysaccharide (LPS) for 16h. After 2h rest, cells were mock treated with control medium. Total RNA was prepared from macrophages 3h after mock treatment. ATC code:---
Control lipopolysaccharide study 6 (mock, LPS)
Macrophages mock treated with control medium for 16h. After 2h rest, cells were treated with 100 ng/ml lipopolysaccharide (LPS). Total RNA was prepared from macrophages 3h after LPS stimulation. ATC code:---

lipopolysaccharide study 6 (mock, LPS) / untreated macrophage sample (C57BL/6) 2

Relative Expression (log2-ratio):-2.849965
Number of Samples:3 / 3
Experimental lipopolysaccharide study 6 (mock, LPS)
Macrophages mock treated with control medium for 16h. After 2h rest, cells were treated with 100 ng/ml lipopolysaccharide (LPS). Total RNA was prepared from macrophages 3h after LPS stimulation. ATC code:---
Control untreated macrophage sample (C57BL/6) 2
Macrophages untreated.

burn injury study 1 (1d; leukocyte) / sham treated leukocyte sample (C57BL/6J; 1d)

Relative Expression (log2-ratio):-2.5339603
Number of Samples:4 / 4
Experimental burn injury study 1 (1d; leukocyte)
Leukocytes isolated from wild type males of C57BL/6J genetic background at 1st day after burn injury.
Control sham treated leukocyte sample (C57BL/6J; 1d)
Leukocytes at 1st day after sham burn injury.

burn injury study 2 (1d; splenocyte) / sham treated splenocyte sample (C57BL/6J; 1d)

Relative Expression (log2-ratio):-2.4910479
Number of Samples:4 / 4
Experimental burn injury study 2 (1d; splenocyte)
Splenocytes isolated from wild type males of C57BL/6J genetic background at 1st day after burn injury.
Control sham treated splenocyte sample (C57BL/6J; 1d)
Splenocytes at 1st day after sham burn injury.

Sjögren syndrome study 3 (8wk; early pre-clinical stage) / normal salivary gland tissue (8wk; C57BL/6)

Relative Expression (log2-ratio):2.128726
Number of Samples:5 / 5
Experimental Sjögren syndrome study 3 (8wk; early pre-clinical stage)
Salivary gland tissue from 8-week-old C57BL/6.NOD-Aec1Aec2 (also known as B6.NOD-Idd5NOD Idd3NOD) male mice representing the early pre-clinical stage of primary Sjögren syndrome (pSS). One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland without any salivary lymph nodes, was analyzed.
Control normal salivary gland tissue (8wk; C57BL/6)
Normal salivary gland tissue from 8-week-old C57BL/6 male mice. One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland without any salivary lymph nodes, was analyzed.

retina development study 1 (P28; NrlkoGfp) / retina development study 1 (P2; NrlkoGfp)

Relative Expression (log2-ratio):2.0631704
Number of Samples:4 / 4
Experimental retina development study 1 (P28; NrlkoGfp)
Retina tissue isolated at postanatal day 28 from NrlkoGFP mouse strain. This strain expresses EGFP under the control of Nrl gene promoter - a retina specific gene and simultenously this gene product is missing.
Control retina development study 1 (P2; NrlkoGfp)
Retina tissue isolated at postanatal day 2 from NrlkoGFP mouse strain. This strain expresses EGFP under the control of Nrl gene promoter - a retina specific gene and simultenously this gene product is missing.

lipopolysaccharide study 6 (LPS/LPS) / lipopolysaccharide study 6 (mock, LPS)

Relative Expression (log2-ratio):1.9713964
Number of Samples:2 / 3
Experimental lipopolysaccharide study 6 (LPS/LPS)
Macrophages were pretreated with 100 ng/ml lipopolysaccharide (LPS) for 16h. After 2h rest, cells were re-stimulated with 100 ng/ml LPS. Total RNA was prepared from macrophages 3h after the second stimulation. ATC code:---
Control lipopolysaccharide study 6 (mock, LPS)
Macrophages mock treated with control medium for 16h. After 2h rest, cells were treated with 100 ng/ml lipopolysaccharide (LPS). Total RNA was prepared from macrophages 3h after LPS stimulation. ATC code:---

lipopolysaccharide study 5 (naive) / untreated macrophage sample (C57BL/6)

Relative Expression (log2-ratio):-1.8262463
Number of Samples:2 / 2
Experimental lipopolysaccharide study 5 (naive)
Macrophages were left untreated (Naive) for 24 hours, washed twice with warm PBS and given 10ng/ml LPS for 4 hours. ATC code:---
Control untreated macrophage sample (C57BL/6)
Macrophages were left untreated (Naive) for 24 hours, washed twice with warm PBS and given fresh media for 4 hours.

melanoma study 10 (tumor; Alk shRNA) / melanoma study 10 (spleen; Alk shRNA)

Relative Expression (log2-ratio):-1.8212872
Number of Samples:3 / 3
Experimental melanoma study 10 (tumor; Alk shRNA)
CD8+ tumor infiltrating T-cell samples transduced with shRNA targeting Alk were isolated from B16-OVA melanoma tumor which was developed in C57BL/6 mouse. IL-7/IL-15 cultured OT-I T cells were transduced with Alk shRNA (pLKO.3G vector). Infected cells were sorted to purity using GFP encoded by the vector as a reporter. OT-I derived T cells transduced with shRNA were injected i.v. into mice bearing day 14 B16-Ova tumors. Seven days later, shRNA-expressing OT-I T cells (CD8+GFP+) were isolated from tumor. B16-Ova tumor cells were injected subcutaneously into C57BL/6 mice.
Control melanoma study 10 (spleen; Alk shRNA)
CD8+ T-cell samples transduced with shRNA targeting Alk were isolated from spleen of mice (C57BL/6) bearing B16-OVA melanoma tumor. IL-7/IL-15 cultured OT-I T cells were transduced with Alk shRNA (pLKO.3G vector). Infected cells were sorted to purity using GFP encoded by the vector as a reporter. OT-I derived T cells transduced with shRNA were injected i.v. into mice bearing day 14 B16-Ova tumors. Seven days later, shRNA-expressing OT-I T cells (CD8+GFP+) were isolated from spleen. B16-Ova tumor cells were injected subcutaneously into C57BL/6 mice.

Sjögren syndrome study 3 (16wk; autoimmunity) / normal salivary gland tissue (16wk; C57BL/6)

Relative Expression (log2-ratio):1.7083807
Number of Samples:4 / 5
Experimental Sjögren syndrome study 3 (16wk; autoimmunity)
Salivary gland tissue from 16-week-old C57BL/6.NOD-Aec1Aec2 (also known as B6.NOD-Idd5NOD Idd3NOD) male mice representing the early clinical phase of autoimmunity, mouse model of primary Sjögren syndrome (pSS). One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland minus any salivary lymph nodes, was analyzed.
Control normal salivary gland tissue (16wk; C57BL/6)
Normal salivary gland tissue from 16-week-old C57BL/6 male mice. One lobe of each salivary gland, which comprised of a submandibular, sublingual, and parotid gland without any salivary lymph nodes, was analyzed.