TOP TEN perturbations for Q9CZ15 (Mus musculus)

Organism: Mus musculus
Gene: Q9CZ15
Selected probe(set): 1452598_at
Platform: Affymetrix Mouse Genome 430 2.0 Array

Expression of Q9CZ15 (1452598_at) across 2697 perturbations tested by GENEVESTIGATOR:

C57BL/6J / AKR/J

Relative Expression (log2-ratio):4.3034086
Number of Samples:3 / 3
Experimental C57BL/6J
Control AKR/J

Nr2e3 knockout study 1 (P30.5) / Nr2e3 knockout study 1 (E18.5)

Relative Expression (log2-ratio):-4.0827904
Number of Samples:3 / 3
Experimental Nr2e3 knockout study 1 (P30.5)
Retinas isolated at postnatal day 30.5 from RD7 mouse strain - a model of retina degeneration.
Control Nr2e3 knockout study 1 (E18.5)
Retinas isolated at embryonic day 18.5 from RD7 mouse strain - a model of retina degeneration.

melanoma study 10 (tumor; Arhgap5 shRNA) / melanoma study 10 (spleen; Arhgap5 shRNA)

Relative Expression (log2-ratio):-4.014842
Number of Samples:3 / 3
Experimental melanoma study 10 (tumor; Arhgap5 shRNA)
CD8+ tumor infiltrating T-cell samples transduced with shRNA targeting Arhgap5 were isolated from B16-OVA melanoma tumor which was developed in C57BL/6 mouse. IL-7/IL-15 cultured OT-I T cells were transduced with Arhgap5 shRNA (pLKO.3G vector). Infected cells were sorted to purity using GFP encoded by the vector as a reporter. OT-I derived T cells transduced with shRNA were injected i.v. into mice bearing day 14 B16-Ova tumors. Seven days later, shRNA-expressing OT-I T cells (CD8+GFP+) were isolated from tumor. B16-Ova tumor cells were injected subcutaneously into C57BL/6 mice.
Control melanoma study 10 (spleen; Arhgap5 shRNA)
CD8+ T-cell samples transduced with shRNA targeting Arhgap5 were isolated from spleen of mice (C57BL/6) bearing B16-OVA melanoma tumor. IL-7/IL-15 cultured OT-I T cells were transduced with Arhgap5 shRNA (pLKO.3G vector). Infected cells were sorted to purity using GFP encoded by the vector as a reporter. OT-I derived T cells transduced with shRNA were injected i.v. into mice bearing day 14 B16-Ova tumors. Seven days later, shRNA-expressing OT-I T cells (CD8+GFP+) were isolated from spleen. B16-Ova tumor cells were injected subcutaneously into C57BL/6 mice.

bone marrow cell differentiation study 1 (Ebf2+) / bone marrow cell differentiation study 1 (Ebf2-)

Relative Expression (log2-ratio):-4.0017786
Number of Samples:3 / 3
Experimental bone marrow cell differentiation study 1 (Ebf2+)
Adult freshly sorted Ebf2+ expressing bone marrow cells purified from bitransgenic Tg(Ebf2-CreERT2 X Rosa26-Yfp) mice. Expression of Ebf2 transcription factor was achieved by intraperitoneal injection of 4mg tamoxifen dissolved in corn oil for five consecutive days.
Control bone marrow cell differentiation study 1 (Ebf2-)
Adult freshly sorted Ebf2- bone marrow cells purified from bitransgenic Tg(Ebf2-CreERT2 X Rosa26-Yfp) mice. Mice were not treated with tamoxifen, thus Ebf2 gene was not expressed.

CAST/EiJ / C57BL/6J

Relative Expression (log2-ratio):-3.9849863
Number of Samples:3 / 3
Experimental CAST/EiJ
The founders were trapped in a grain warehouse in Thailand. Mice were sent to Dr. Eva Eicher and Dr. Thomas Roderick at The Jackson Laboratory in 1971. Dr. Eicher's colony was maintained by inbreeding to generate CAST/Ei.
Control C57BL/6J

eye development study 1 (retina; adult; wt) / eye development study 1 (retina; P4; wt)

Relative Expression (log2-ratio):-3.908166
Number of Samples:2 / 3
Experimental eye development study 1 (retina; adult; wt)
Left and right total retinas isolated from adult wildtype male mice of C57BL/6J strain. Isolation took place after retinal ganglion cell segregation in lateral geniculate nucleus. Retinas from each animal were separated from the sclera.
Control eye development study 1 (retina; P4; wt)
Left and right total retinas isolated from wildtype male mice of C57BL/6J strain at postnatal day 4. Isolation took place before retinal ganglion cell segregation in lateral geniculate nucleus. Retinas from each animal were separated from the sclera.

NOD.NON-H2nb1/LtJ / C57BL/6J

Relative Expression (log2-ratio):-3.7641554
Number of Samples:3 / 3
Experimental NOD.NON-H2nb1/LtJ
These mice carry the diabetes-resistant MHC from the NON/LtJ strain, and are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes. Synonyms:NOD.H2nb1 JAX:
Control C57BL/6J

melanoma study 10 (tumor; Alk shRNA) / melanoma study 10 (spleen; Alk shRNA)

Relative Expression (log2-ratio):-3.7249365
Number of Samples:3 / 3
Experimental melanoma study 10 (tumor; Alk shRNA)
CD8+ tumor infiltrating T-cell samples transduced with shRNA targeting Alk were isolated from B16-OVA melanoma tumor which was developed in C57BL/6 mouse. IL-7/IL-15 cultured OT-I T cells were transduced with Alk shRNA (pLKO.3G vector). Infected cells were sorted to purity using GFP encoded by the vector as a reporter. OT-I derived T cells transduced with shRNA were injected i.v. into mice bearing day 14 B16-Ova tumors. Seven days later, shRNA-expressing OT-I T cells (CD8+GFP+) were isolated from tumor. B16-Ova tumor cells were injected subcutaneously into C57BL/6 mice.
Control melanoma study 10 (spleen; Alk shRNA)
CD8+ T-cell samples transduced with shRNA targeting Alk were isolated from spleen of mice (C57BL/6) bearing B16-OVA melanoma tumor. IL-7/IL-15 cultured OT-I T cells were transduced with Alk shRNA (pLKO.3G vector). Infected cells were sorted to purity using GFP encoded by the vector as a reporter. OT-I derived T cells transduced with shRNA were injected i.v. into mice bearing day 14 B16-Ova tumors. Seven days later, shRNA-expressing OT-I T cells (CD8+GFP+) were isolated from spleen. B16-Ova tumor cells were injected subcutaneously into C57BL/6 mice.

eye development study 1 (retina; adult; Picciotto b2 -/-) / eye development study 1 (retina; P4; Picciotto b2 -/-)

Relative Expression (log2-ratio):-3.5624561
Number of Samples:2 / 3
Experimental eye development study 1 (retina; adult; Picciotto b2 -/-)
Left and right total retinas isolated from adult male Chrnb2 knockout mice (after retinal ganglion cell segregation in lateral geniculate nucleus). Mice were initially mutated by Picciotto (Picciotto b2 -/-, PMID: 7870173) and on C57BL/6J genetic background. Retinas from each animal were separated from the sclera. Chrnb2=cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal).
Control eye development study 1 (retina; P4; Picciotto b2 -/-)
Left and right total retinas isolated from male Chrnb2 knockout mice at postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus). Mice were initially mutated by Picciotto (Picciotto b2 -/-, PMID: 7870173) and on C57BL/6J genetic background. Retinas from each animal were separated from the sclera. Chrnb2=cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal).

eye development study 1 (retina; adult; Xu b2 -/-) / eye development study 1 (retina; P4; Xu b2 -/-)

Relative Expression (log2-ratio):-3.5158558
Number of Samples:2 / 3
Experimental eye development study 1 (retina; adult; Xu b2 -/-)
Left and right total retinas isolated from adult male Chrnb2 knockout mice (after retinal ganglion cell segregation in lateral geniculate nucleus). Mice were initially mutated by Xu (Xu b2 -/-, PMID: 10531434) and on C57BL/6J genetic background. Retinas from each animal were separated from the sclera. Chrnb2=cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal).
Control eye development study 1 (retina; P4; Xu b2 -/-)
Left and right total retinas isolated from male Chrnb2 knockout mice at postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus). Mice were initially mutated by Xu (Xu b2 -/-, PMID: 10531434) and on C57BL/6J genetic background. Retinas from each animal were separated from the sclera. Chrnb2=cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal).