TOP TEN perturbations for D3ZG44 (Rattus norvegicus)

Organism: Rattus norvegicus
Gene: D3ZG44
Selected probe(set): 1385545_at
Platform: Affymetrix Rat Genome 230 2.0 Array

Expression of D3ZG44 (1385545_at) across 7611 perturbations tested by GENEVESTIGATOR:

ethionine study 12 (250mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.190979
Number of Samples:3 / 3
Experimental ethionine study 12 (250mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: ethionine (250mg/kg; CHEMBL203187). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

ethionine study 12 (80mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.1290169
Number of Samples:3 / 3
Experimental ethionine study 12 (80mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: ethionine (80mg/kg; CHEMBL203187). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

methapyrilene study 8 (100mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):-1.0191832
Number of Samples:3 / 3
Experimental methapyrilene study 8 (100mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: methapyrilene (100mg/kg; CHEMBL1411979). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

TCDD study 5 (Wistar Han; 10d) / TCDD study 5 (Wistar Han; 4d)

Relative Expression (log2-ratio):-0.9983654
Number of Samples:5 / 4
Experimental TCDD study 5 (Wistar Han; 10d)
Liver samples from 11-15 weeks old TCDD-resistant Wistar Han (Kuopio) male rats treated with compound: TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin; 100 ug/kg; vehicle: corn oil) for 10 days. ATC code:---
Control TCDD study 5 (Wistar Han; 4d)
Liver samples from 11-15 weeks old TCDD-resistant Wistar Han (Kuopio) male rats treated with compound: TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin; 100 ug/kg; vehicle: corn oil) for 4 days. ATC code:---

acetamidofluorene study 2 (300mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):-0.9765644
Number of Samples:3 / 3
Experimental acetamidofluorene study 2 (300mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: acetamidofluorene (300mg/kg; CHEMBL311469). Rats were treated by gavage and sacrificed after 6 hours of treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage and sacrificed after 6 hours.

phenacetin study 2 (1000mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):-0.90104103
Number of Samples:3 / 3
Experimental phenacetin study 2 (1000mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: phenacetin (1000mg/kg; CHEMBL16073). Rats were treated by gavage and sacrificed after 6 hours of treatment. ATC code:
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage and sacrificed after 6 hours.

carbon tetrachloride study 11 (400 mg/kg) / vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):-0.8817377
Number of Samples:2 / 28
Experimental carbon tetrachloride study 11 (400 mg/kg)
Liver samples from Crj:CD(SD)IGS rats treated with compound: carbon tetrachloride (400 mg/kg; vehicle: corn oil) for 0.25 days. ATC code:---
Control vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (corn oil). Rats were sacrificed 0.25 days after the last treatment.

carboplatin study 18 (3000uM) / vehicle treated (medium) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):-0.8619213
Number of Samples:2 / 2
Experimental carboplatin study 18 (3000uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: carboplatin (3000uM; CHEMBL288376). Hepatocytes were treated for 8 hours. ATC code:
Control vehicle treated (medium) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (medium). Hepatocytes were vehicle treated for 8 hours.

acetamidofluorene study 2 (1000mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):-0.8500643
Number of Samples:3 / 3
Experimental acetamidofluorene study 2 (1000mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: acetamidofluorene (1000mg/kg; CHEMBL311469). Rats were treated by gavage and sacrificed after 6 hours of treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage and sacrificed after 6 hours.

glucosamine (20mM); IL-1b (10ng/ml) study 1 / untreated chondrocyte sample (Wistar)

Relative Expression (log2-ratio):0.8376999
Number of Samples:4 / 3
Experimental glucosamine (20mM); IL-1b (10ng/ml) study 1
Chondrocytes were treated with glucosamine, HCl (20mM). Six hours later, the cells received IL-1beta (10 ng/ml). Fourteen hours post IL-1beta stimulation, total RNA was isolated from the cultures and microarray experiments were processed. ATC code:
Control untreated chondrocyte sample (Wistar)
Untreated chondrocytes.