TOP TEN perturbations for P84100 (Rattus norvegicus)

Organism: Rattus norvegicus
Gene: P84100
Selected probe(set): 1367610_at
Platform: Affymetrix Rat Genome 230 2.0 Array

Expression of P84100 (1367610_at) across 7639 perturbations tested by GENEVESTIGATOR:

axotomy study 1 / untreated, naive cortical axon cell sample (Sprague Dawley)

Relative Expression (log2-ratio):-3.8707848
Number of Samples:3 / 7
Experimental axotomy study 1
Axons of dissociated cortical neurons from 18 days old Sprague Dawley embryos, cultured for 13 days. For axotomized culture samples, axons were removed by aspiration after 11 days in culture, then allowed to regrow for 2 days before harvesting.
Control untreated, naive cortical axon cell sample (Sprague Dawley)
Untreated axons of dissociated cortical neurons from 18 days old Sprague Dawley embryos, cultured for 13 days.

dextran sulphate sodium study 1 (early) / untreated full-thickness colon tissue (Sprague Dawley)

Relative Expression (log2-ratio):-1.4355202
Number of Samples:12 / 6
Experimental dextran sulphate sodium study 1 (early)
Dextran sulphate sodium (DSS) induced colitis as model for inflammatory bowel disease: full-thickness colon tissue samples of female Sprague Dawley rats retrieving 5% DSS in drinking water from day 1 to 7. Samples were taken 1, 3, 5 and 7 days after application of DSS. ATC code:---
Control untreated full-thickness colon tissue (Sprague Dawley)
Full-thickness colon tissue samples of untreated female Sprague Dawley rats retrieving water only.

methapyrilene study 8 (100mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.1808262
Number of Samples:3 / 3
Experimental methapyrilene study 8 (100mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: methapyrilene (100mg/kg; CHEMBL1411979). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

acetamidofluorene study 7 (30mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.1596069
Number of Samples:3 / 3
Experimental acetamidofluorene study 7 (30mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: acetamidofluorene (30mg/kg; CHEMBL311469). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment.

methapyrilene study 7 (100mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.1422024
Number of Samples:3 / 3
Experimental methapyrilene study 7 (100mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: methapyrilene (100mg/kg; CHEMBL1411979). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment. ATC code:
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment.

acetamidofluorene study 7 (100mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.1189594
Number of Samples:3 / 3
Experimental acetamidofluorene study 7 (100mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: acetamidofluorene (100mg/kg; CHEMBL311469). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment.

aminosalicylic acid study 2 (2337 mg/kg) / vehicle treated (CMC) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.0671387
Number of Samples:3 / 18
Experimental aminosalicylic acid study 2 (2337 mg/kg)
Liver samples from Crj:CD(SD)IGS rats treated with compound: aminosalicylic acid (2337 mg/kg; vehicle: CMC) for 5 days. ATC code:$atc_code$
Control vehicle treated (CMC) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (CMC). Rats were sacrificed 5 days after the last treatment.

nitrosodiethylamine study 6 (30mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.0655708
Number of Samples:3 / 3
Experimental nitrosodiethylamine study 6 (30mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: nitrosodiethylamine (30mg/kg; CHEMBL164290). Rats were treated by gavage once daily for 7 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 7 days and sacrificed 24 hours after the last treatment.

acetamidofluorene study 8 (30mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.0609226
Number of Samples:3 / 3
Experimental acetamidofluorene study 8 (30mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: acetamidofluorene (30mg/kg; CHEMBL311469). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

monocrotaline study 11 (30mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.0314159
Number of Samples:3 / 3
Experimental monocrotaline study 11 (30mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: monocrotaline (30mg/kg; CHEMBL521035). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 14 days and sacrificed 24 hours after the last treatment.