TOP TEN perturbations for Q4KM86 (Rattus norvegicus)

Organism: Rattus norvegicus
Gene: Q4KM86
Selected probe(set): 1392725_at
Platform: Affymetrix Rat Genome 230 2.0 Array

Expression of Q4KM86 (1392725_at) across 7639 perturbations tested by GENEVESTIGATOR:

gentamicin study 10 (100mg/kg) / vehicle treated (saline) kidney tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.7569828
Number of Samples:3 / 3
Experimental gentamicin study 10 (100mg/kg)
Kidney samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: gentamicin (100mg/kg; CHEMBL1201259). Rats were treated by intravenous injection and sacrificed after 24 hours of treatment. ATC code:, , , ,
Control vehicle treated (saline) kidney tissue samples (Crj:CD(SD)IGS)
Kidney samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (saline). Rats were treated by intravenous injection and sacrificed after 24 hours.

phenobarbital study 19 (50mg/kg/day; 14d; mesenchymal cells) / normal mesenchymal cell sample (14d; Wistar Han)

Relative Expression (log2-ratio):-1.7118645
Number of Samples:3 / 3
Experimental phenobarbital study 19 (50mg/kg/day; 14d; mesenchymal cells)
Mesenchymal cells from 10 weeks old male Wistar Han rats treated with phenobarbital (50 mg/kg/day; vehicle: water) for 14 days. ATC code:
Control normal mesenchymal cell sample (14d; Wistar Han)
Mesenchymal cell samples from 10 weeks old male Wistar Han rats.

kidney development study 3 (P28) / kidney development study 3 (E13)

Relative Expression (log2-ratio):1.6192102
Number of Samples:3 / 3
Experimental kidney development study 3 (P28)
Kidney tissue isolated from rat (unspecified strain) at the postnatal week 4 (P28).
Control kidney development study 3 (E13)
Kidney tissue isolated from rat (unspecified strain) at the embryonic day 13.

N,N-dimethylformamide study 5 (1400 mg/kg) / vehicle treated (saline) kidney tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.4607534
Number of Samples:2 / 15
Experimental N,N-dimethylformamide study 5 (1400 mg/kg)
Kidney samples from Crj:CD(SD)IGS rats treated with compound: N,N-dimethylformamide (1400 mg/kg; vehicle: saline) for 3 days. ATC code:---
Control vehicle treated (saline) kidney tissue samples (Crj:CD(SD)IGS)
Kidney samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (saline). Rats were sacrificed 3 days after the last treatment.

allopurinol study 16 (150mg/kg) / vehicle treated (0.5% methylcellulose) kidney tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):-1.2836914
Number of Samples:3 / 3
Experimental allopurinol study 16 (150mg/kg)
Kidney samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: allopurinol (150mg/kg; CHEMBL1467). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:
Control vehicle treated (0.5% methylcellulose) kidney tissue samples (Crj:CD(SD)IGS)
Kidney samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

galactosamine study 3 (48h; 750mg/kg ip; 9d vehicle oral) / vehicle treated liver tissue (Brown Norway; 48h vehicle ip; 9d vehicle oral)

Relative Expression (log2-ratio):1.2623281
Number of Samples:2 / 3
Experimental galactosamine study 3 (48h; 750mg/kg ip; 9d vehicle oral)
Liver tissue obtained from female rats treated with one dose of galactosamine (750mg/kg) 48 hours before sacrifice, and oral gavage of vehicle (0.5% hydroxypropyl methylcellulose, HPMC) for 9 days. Rats were of strain Brown Norway, Bn/Crl, with strain code 091 and MHC haplotype RT1n, and 86-95 days old. ATC code:---
Control vehicle treated liver tissue (Brown Norway; 48h vehicle ip; 9d vehicle oral)
Vehicle treated liver tissue obtained from female rats. Rats received intraperitoneal injection of vehicle (saline) 48 hours before sacrifice, and oral gavage of vehicle (0.5% hydroxypropyl methylcellulose, HPMC) for 9 days. Rats were of strain Brown Norway, Bn/Crl, with strain code 091 and MHC haplotype RT1n, and 86-93 days old.

ethionine study 12 (250mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.2613745
Number of Samples:3 / 3
Experimental ethionine study 12 (250mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: ethionine (250mg/kg; CHEMBL203187). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

fenofibrate study 20 (100 mg/kg) / vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.245923
Number of Samples:3 / 18
Experimental fenofibrate study 20 (100 mg/kg)
Liver samples from Crj:CD(SD)IGS rats treated with compound: fenofibrate (100 mg/kg; vehicle: corn oil) for 1 day. ATC code:
Control vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (corn oil). Rats were sacrificed 1 day after the last treatment.

N,N-dimethylformamide study 13 (1400 mg/kg) / vehicle treated (saline) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.2351189
Number of Samples:2 / 18
Experimental N,N-dimethylformamide study 13 (1400 mg/kg)
Liver samples from Crj:CD(SD)IGS rats treated with compound: N,N-dimethylformamide (1400 mg/kg; vehicle: saline) for 3 days. ATC code:---
Control vehicle treated (saline) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (saline). Rats were sacrificed 3 days after the last treatment.

etoposide study 11 (350uM) / vehicle treated (DMSO) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):1.1968536
Number of Samples:2 / 2
Experimental etoposide study 11 (350uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: etoposide (350uM; CHEMBL44657). Hepatocytes were treated for 24 hours. ATC code:
Control vehicle treated (DMSO) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (DMSO). Hepatocytes were vehicle treated for 24 hours.