TOP TEN perturbations for Q8VIJ4 (Rattus norvegicus)

Organism: Rattus norvegicus
Gene: Q8VIJ4
Selected probe(set): 1370413_at
Platform: Affymetrix Rat Genome 230 2.0 Array

Expression of Q8VIJ4 (1370413_at) across 7639 perturbations tested by GENEVESTIGATOR:

3Y1-B clone 1-MUC1 / 3Y1-B clone 1-con

Relative Expression (log2-ratio):-4.509014
Number of Samples:2 / 2
Experimental 3Y1-B clone 1-MUC1
Rat 3Y1-B clone 1 embryonic fibroblast culture cell line stably transfected with an expression vector expressing the cytoplasmic domain of the oncoprotein MUC1p. Synonyms:3Y1/MUC1-CD Parental cell line:: Rat 3Y1-B clone 1
Control 3Y1-B clone 1-con
Rat 3Y1-B clone 1 embryonic fibroblast modified by stable control transfection. Parental cell line:: Rat 3Y1-B clone 1

ethionine study 19 (10000uM) / vehicle treated (medium) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):-2.030178
Number of Samples:2 / 2
Experimental ethionine study 19 (10000uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: ethionine (10000uM; CHEMBL203187). Hepatocytes were treated for 24 hours. ATC code:---
Control vehicle treated (medium) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (medium). Hepatocytes were vehicle treated for 24 hours.

ethionine study 18 (10000uM) / vehicle treated (medium) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):-1.7006216
Number of Samples:2 / 2
Experimental ethionine study 18 (10000uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: ethionine (10000uM; CHEMBL203187). Hepatocytes were treated for 8 hours. ATC code:---
Control vehicle treated (medium) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (medium). Hepatocytes were vehicle treated for 8 hours.

sporidesmin A study 2 (0.15 uM) / vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):-1.6961508
Number of Samples:3 / 59
Experimental sporidesmin A study 2 (0.15 uM)
Hepatocytes samples from Crj:CD(SD)IGS rats treated with compound: sporidesmin A (0.15 uM; vehicle: DMSO) for 1 day. ATC code:---
Control vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)
Hepatocytes samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (DMSO). Rats were sacrificed 1 day after the last treatment.

ethionine study 19 (2000uM) / vehicle treated (medium) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):-1.6586666
Number of Samples:2 / 2
Experimental ethionine study 19 (2000uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: ethionine (2000uM; CHEMBL203187). Hepatocytes were treated for 24 hours. ATC code:---
Control vehicle treated (medium) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (medium). Hepatocytes were vehicle treated for 24 hours.

kidney development study 3 (P28) / kidney development study 3 (E13)

Relative Expression (log2-ratio):-1.4014282
Number of Samples:3 / 3
Experimental kidney development study 3 (P28)
Kidney tissue isolated from rat (unspecified strain) at the postnatal week 4 (P28).
Control kidney development study 3 (E13)
Kidney tissue isolated from rat (unspecified strain) at the embryonic day 13.

thioacetamide study 12 (45mg/kg) / vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.399643
Number of Samples:3 / 3
Experimental thioacetamide study 12 (45mg/kg)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with compound: thioacetamide (45mg/kg; CHEMBL38737). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment. ATC code:---
Control vehicle treated (0.5% methylcellulose) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (0.5% methylcellulose). Rats were treated by gavage once daily for 28 days and sacrificed 24 hours after the last treatment.

ethionine study 18 (2000uM) / vehicle treated (medium) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):-1.3953876
Number of Samples:2 / 2
Experimental ethionine study 18 (2000uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: ethionine (2000uM; CHEMBL203187). Hepatocytes were treated for 8 hours. ATC code:---
Control vehicle treated (medium) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (medium). Hepatocytes were vehicle treated for 8 hours.

dexamethasone study 12 (150 mg/kg) / vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.3663912
Number of Samples:3 / 28
Experimental dexamethasone study 12 (150 mg/kg)
Liver samples from Crj:CD(SD)IGS rats treated with compound: dexamethasone (150 mg/kg; vehicle: corn oil) for 0.25 days. ATC code:, , , , , , , , , ,
Control vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (corn oil). Rats were sacrificed 0.25 days after the last treatment.

nafenopin study 2 (338 mg/kg) / vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):1.3661499
Number of Samples:3 / 18
Experimental nafenopin study 2 (338 mg/kg)
Liver samples from Crj:CD(SD)IGS rats treated with compound: nafenopin (338 mg/kg; vehicle: corn oil) for 3 days. ATC code:---
Control vehicle treated (corn oil) liver tissue samples (Crj:CD(SD)IGS)
Liver samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (corn oil). Rats were sacrificed 3 days after the last treatment.