TOP TEN perturbations for Q91XU7 (Rattus norvegicus)

Organism: Rattus norvegicus
Gene: Q91XU7
Selected probe(set): 1367888_at
Platform: Affymetrix Rat Genome 230 2.0 Array

Expression of Q91XU7 (1367888_at) across 7605 perturbations tested by GENEVESTIGATOR:

isoniazid study 11 (10000uM) / vehicle treated (medium) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):5.298217
Number of Samples:2 / 2
Experimental isoniazid study 11 (10000uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: isoniazid (10000uM; CHEMBL64). Hepatocytes were treated for 24 hours. ATC code:
Control vehicle treated (medium) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (medium). Hepatocytes were vehicle treated for 24 hours.

heart development study 1 (P49; N2BA:N2B mutant) / heart development study 1 (P1; N2BA:N2B mutant)

Relative Expression (log2-ratio):-5.0842285
Number of Samples:3 / 3
Experimental heart development study 1 (P49; N2BA:N2B mutant)
Heart tissue isolated at postnatal day 49 from a rat strain with an autosomal dominant mutation in the gene enconding RNA binding motif protein 20 (Rbm20). This mutation leads to the opposite cardiac titin isoform expression as compared to wild type developmental stages (N2BA:N2B), and to many phenotypic features that are observed in individuals with cardiomyopathy related to mutant RBM20.
Control heart development study 1 (P1; N2BA:N2B mutant)
Heart tissue isolated at postnatal day 1 from a rat strain with an autosomal dominant mutation in the gene enconding RNA binding motif protein 20 (Rbm20). This mutation leads to the opposite cardiac titin isoform expression as compared to wild type developmental stages (N2BA:N2B), and to many phenotypic features that are observed in individuals with cardiomyopathy related to mutant RBM20.

heart development study 1 (P20; N2BA:N2B mutant) / heart development study 1 (P1; N2BA:N2B mutant)

Relative Expression (log2-ratio):-4.880517
Number of Samples:3 / 3
Experimental heart development study 1 (P20; N2BA:N2B mutant)
Heart tissue isolated at postnatal day 20 from a rat strain with an autosomal dominant mutation in the gene enconding RNA binding motif protein 20 (Rbm20). This mutation leads to the opposite cardiac titin isoform expression as compared to wild type developmental stages (N2BA:N2B), and to many phenotypic features that are observed in individuals with cardiomyopathy related to mutant RBM20.
Control heart development study 1 (P1; N2BA:N2B mutant)
Heart tissue isolated at postnatal day 1 from a rat strain with an autosomal dominant mutation in the gene enconding RNA binding motif protein 20 (Rbm20). This mutation leads to the opposite cardiac titin isoform expression as compared to wild type developmental stages (N2BA:N2B), and to many phenotypic features that are observed in individuals with cardiomyopathy related to mutant RBM20.

heart development study 1 (P20; SDF344) / heart development study 1 (P1; SDF344)

Relative Expression (log2-ratio):-4.4312162
Number of Samples:3 / 3
Experimental heart development study 1 (P20; SDF344)
Heart tissue isolated from a hybrid rat strain at postnatal day 20. The Sprague-Dawley rats with wild type titin profile were crossed with Fisher 344 inbreds. Both strains were obtained from Harlan Sprague Dawley.
Control heart development study 1 (P1; SDF344)
Heart tissue isolated from a hybrid rat strain at postnatal day 1. The Sprague-Dawley rats with wild type titin profile were crossed with Fisher 344 inbreds. Both strains were obtained from Harlan Sprague Dawley.

heart development study 1 (P49; SDF344) / heart development study 1 (P1; SDF344)

Relative Expression (log2-ratio):-4.3611746
Number of Samples:3 / 3
Experimental heart development study 1 (P49; SDF344)
Heart tissue isolated from a hybrid rat strain at postnatal day 49. The Sprague-Dawley rats with wild type titin profile were crossed with Fisher 344 inbreds. Both strains were obtained from Harlan Sprague Dawley.
Control heart development study 1 (P1; SDF344)
Heart tissue isolated from a hybrid rat strain at postnatal day 1. The Sprague-Dawley rats with wild type titin profile were crossed with Fisher 344 inbreds. Both strains were obtained from Harlan Sprague Dawley.

vinblastine study 7 (45 uM) / vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):3.4283562
Number of Samples:3 / 59
Experimental vinblastine study 7 (45 uM)
Hepatocytes samples from Crj:CD(SD)IGS rats treated with compound: vinblastine (45 uM; vehicle: DMSO) for 1 day. ATC code:
Control vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)
Hepatocytes samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (DMSO). Rats were sacrificed 1 day after the last treatment.

synapse development study 2 (P21) / synapse development study 2 (P3)

Relative Expression (log2-ratio):-3.2673779
Number of Samples:5 / 6
Experimental synapse development study 2 (P21)
Globular bushy cells (GBC) were isolated from 12 um thick slices of ventral cochlear nucleus using laser microdissection at postnatal day 21 (P21). GBCs were retrogradely labeled by stereotaxic injection of fluorescent (Alexa 488 or 596) cholera toxin-B (CTB) at postnatal day 20. Approximately 1.5 ul of CTB solution [1 mg/ml in phosphate-buffered saline (PBS)] was slowly injected into the contralateral medial nucleus of the trapezoid body nucleus. At this time point calyx is fully mature. 200 CTB-labeled cells collected from the same animal represent one sample.
Control synapse development study 2 (P3)
Globular bushy cells (GBC) were isolated from 12 um thick slices of the ventral cochlear nucleus using laser microdissection at postnatal day 3 (P3). GBCs were retrogradely labeled by stereotaxic injection of fluorescent (Alexa 488 or 596) cholera toxin-B (CTB) at postnatal day 2. Approximately 1.5 ul of CTB solution [1 mg/ml in phosphate-buffered saline (PBS)] was slowly injected into the contralateral medial nucleus of the trapezoid body nucleus. At this time point there is a calyx of Held formation. 200 CTB-labeled cells collected from the same animal represent one sample.

sparteine study 2 (2222 uM) / vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):2.8345556
Number of Samples:3 / 59
Experimental sparteine study 2 (2222 uM)
Hepatocytes samples from Crj:CD(SD)IGS rats treated with compound: sparteine (2222 uM; vehicle: DMSO) for 1 day. ATC code:
Control vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)
Hepatocytes samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (DMSO). Rats were sacrificed 1 day after the last treatment.

disopyramide study 11 (2500uM) / vehicle treated (medium) hepatocyte samples (Sprague Dawley)

Relative Expression (log2-ratio):2.6172495
Number of Samples:2 / 2
Experimental disopyramide study 11 (2500uM)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with compound: disopyramide (2500uM; CHEMBL517). Hepatocytes were treated for 24 hours. ATC code:
Control vehicle treated (medium) hepatocyte samples (Sprague Dawley)
Hepatocyte samples derived from 6 weeks old male Sprague Dawley rats, treated with vehicle (medium). Hepatocytes were vehicle treated for 24 hours.

ethinylestradiol study 21 (190 uM) / vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)

Relative Expression (log2-ratio):2.303423
Number of Samples:3 / 59
Experimental ethinylestradiol study 21 (190 uM)
Hepatocytes samples from Crj:CD(SD)IGS rats treated with compound: ethinylestradiol (190 uM; vehicle: DMSO) for 1 day. ATC code:,
Control vehicle treated (DMSO) hepatocytes tissue samples (Crj:CD(SD)IGS)
Hepatocytes samples derived from 6 weeks old male Crj:CD(SD)IGS rats, treated with vehicle (DMSO). Rats were sacrificed 1 day after the last treatment.